Cell cycle genes

Wang JM, Johnston PB, Ball BG, Brinton RD. The neurosteroid allopregnano-lone promotes proliferation of rodent and human neural progenitor cells and regulates cell-cycle gene and protein expression. J Neurosci 2005 25 4706-18. 

Jimenez, J., Alphey, L., Nurse, P, and Glover, D. M. (1990). Complementation of fission yeast cdc2,s and cdc25a mutants identifies two cell cycle genes from Drosophila a cdc2 homologue and string. EMBO J. 9 3565-3571. 

Edgar I could offer one idea of what GO is. When the cells we study in Drosophila are ready to differentiate, they turn off all their cell cycle genes. They are limited for everything DNA polymerase, Cdc25, cyclin E and E2F. We consider these cells GO cells. 

Nasmyth The work by Gareth Williams and Ron Laskey with the MCM proteins in cervical cancer is an example of a cell cycle gene that is presumably part of some huge battery of genes that is somehow related to whether the cell is in a proliferative state. It turns out to be rather a good marker for tumour cells. But it is nothing directly to do with proliferation itself. 

Nurse One thing we haven t talked much about is how cell cycle genes are developmentally patterned, as worked out by promoter bashing. This is something that could be informative has it been ... 

Nasmyth The question is, will their regulation be any different from that of things that aren t cell cycle regulators At the end of the day the String promoter is the promoter of a cell cycle gene, but would you learn anything new about transcription ... 

Edgar The competing model will be that fancy promoters are not used to control cell cycle genes, but instead there is some kind of growth coupling mechanism. 

McGrath, J. P., Varshavsky, A., and Byers, B. The yeast cell cycle gene CDG34 encodes a ubiquitin-conjugating enzyme. Science 1988,... 

Figure 2. Mechanisms and signalings of neuronal death. Death can be initiated at the membrane by activation of death domain receptors (DDR), or by intracellular signalings through oxidative stress (and the production of reactive oxigen species, ROS), perturbed calcium homeostasis, mitochondrial dysfunction (release of cytochrome c, cytC), activation of caspases, as well as reactivation of cell cycle genes such as the transcription factor E2F (see text). Interconnections have been demonstrated (dotted lines) depending on the apoptotic context...

Davis T, Kennedy C, Chiew YE, Clarke CL, deEaxio A. (2000) Histone deacetylase inhibitors decrease proliferation and modulate cell cycle gene expression in normal mammary epithelial cells. Clin Cancer Res 6 4334 342. 

Burger C, Wick M, Muller R (1994) Lineage-specific regulation of cell cycle gene expression in differentiating myeloid cells. J Cell Sci 107 2047-2054... 

Nishitani, H. lygerou, Z. (2002) Control of DNA replication licensing in a cell cycle. Genes Cells 7, 523-534. 

Levites Y, Amit T, Youdim MB, Mandel S. 2002a. Involvement of protein kinase C activation and cell survival/ cell cycle genes in green tea polyphenol (—)-epigalloca-techin 3-gallate neuroprotective action. J Biol Chem 277 30574-30580. 

A. Queen, S.. Gong, M. Rtmann, and C. Basilieo. Qguiizalion and expression of the cell cycle gene, till, that encodes asparagine synthetase Mo/. CelL BioL 92350 (1989). 

Nasmyth, K. A., and S. I. Reed. 1980. Isolation of genes by complementation in yeast molecular cloning of a cell-cycle gene. Proc. Natl Acad. Sci. USA 77 2119-2123. 

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