Biotin in Regulation of the Cell Cycle

Biotin is essential for cell proliferation. Peripheral blood mononucleeu cells appear to take up biotin by a system that is distinct from the sodium-dependent multivitamin tremsporter that is responsible for intestinal and reneil upteike of biotin (Section 11.1). In response to mitogenic stimuli the uptake of biotin increases several-fold, with no change in the activity of the sodium-dependent transporter. At the same time, there is an increeise in the rate of expression of methylcrotonyl CoA, propionyl CoA ctirboxylases, and holocenboxylase 

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