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Cell-cycle-nonspecific cytotoxic

Thiotepa is an alkylating agent, which is a cell-cycle nonspecific alkylating agent related to nitrogen mustard. Its radiomimetic action is believed to occur through the release of ethylenimine radicals, which disrupt the bonds of DNA. TEPA possesses cytotoxic activity. [Pg.687]

Cyclophosphamide is a cytotoxic (cytostatic), cell cycle nonspecific, antiproliferative agent which is used in such diverse medical problems as neoplasia, tissue transplantation and inflammatory diseases. Chemically, it is an inert bioprecursor for a potent nitrogen mustard alkylation agent (Fig. 33.31). [Pg.577]

Antineoplastic anthracycUne drug (cell cycle-nonspecific) intercalates between base pairs to disrupt DNA functions, inhibits topoisomerases, and forms cytotoxic free radicals. Tox cardiotoxicity (consider dexrazoxane), myelosuppres.sion. Daunorubicin is similar. [Pg.554]

See other pages where Cell-cycle-nonspecific cytotoxic is mentioned: [Pg.409]    [Pg.104]    [Pg.346]    [Pg.112]    [Pg.575]    [Pg.189]    [Pg.2292]    [Pg.2293]    [Pg.469]    [Pg.858]    [Pg.107]    [Pg.13]   


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Cell cycle

Cytotoxic agents cell-cycle-nonspecific

Cytotoxic cells

Cytotoxicity cells

Nonspecificity

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