Apigenin cell cycle arrest induced

Studies Testing the Hypothesis that Apigenin Inhibits Colon Carcinogenesis by inducing Cell Cycle Arrest... 

Suppressing mechanism This mechanism includes elimination of tumor cells, including growth inhibition by induction of cell-cycle arrest or apoptosis. Apigenin has been shown to induce G2/M arrest in SW480 and Caco-2 human colon carcinoma cells [40], Resveratrol and quercetin are reported to induce the expression of caspase-3 promoting apoptosis, arresting cells in G1 phase of the cell cycle, and decrease tiunor cell invasion [41]. 

Takagaki N, Sowa Y, Oki T (2005) Apigenin induces cell cycle arrest and p21/WAFl expression in a p53-independent pathway. Int J Oncol 26 185-189 Lim do Y, Jeong Y, Tyner AL et al (2007) Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin. Am J Physiol Gastrointest Liver Physiol 292 G66-G75... 

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