Hepatocyte growth factor receptor

All RTKs contain between one and three tyrosines in the kinase activation loop, which is composed of subdomains VII and VIII of the protein kinase catalytic core. Phosphorylation of these tyrosines has been shown to be critical for stimulation of catalytic activity and biological function for a number of RTKs, including insulin receptor, FGF receptor, VEGF receptor, PDGF receptor, Met (hepatocyte growth factor receptor), and TrkA (NGF receptor). A major exception is the EGF receptor, for which autophosphorylation of a conserved tyrosine in the activation loop does not seem to be involved in signaling. Substitution of tyrosine with phenylalanine has no effect on RTK activity or downstream signals. 

Insulin-like growth factor receptor (IGFR) Colony-stimulating factor receptor (CSFR) Nerve growth factor receptor (NGFR) Hepatocyte growth factor receptor (Met) Glial-derived neurotrophic factor receptor (RET)... 

Crizotinib (Xalkori ) 2011 ALK, hepatocyte growth factor receptor (HGFR cMet) Anaplastic lymphoma kinase (ALK)-positive NSCLC... 

Inoue, K., Chikazawa, M., Karashima, T., Iiyama, T., Kamada, M., et al., Overexpression of c-Met/hepatocyte growth factor receptors in human prostatic adenocarcinoma. Acta Medica Okayama 52, 305-310 (1998). 

Kashiwakura Y, Tamayose K, Iwabuchi K, Hirai Y, Shimada T, Matsumoto K, Nakamura T, Watanabe M, Oshimi K, Daida H. Hepatocyte growth factor receptor is a coreceptor for adeno-associated virus type 2 infection. J Virol 2005 79 609-614. 

Met/hepatocyte growth factor receptor tyrosine kinase <45> [121]... 

Ferracini, R. Longati, R Naldini, L. Vigna, E. Comoglio, P.M. Identification of the major autophosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase. J. Biol. Chem., 266, 19558-19564 (1991)... 

Bottaro, D.P. et al., Identification of the hepatocyte growth factor receptor as the c-met protooncogene product, Science, 251, 802,1991. 

Maulik, G. et al. Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition. Cytokine Growth Factor Rev., 13,41,2002. 

Liu, Y., The human hepatocyte growth factor receptor gene complete structural organization and promoter characterization. Gene, 215,159,1998. 

Lin HC, Lai PY, Lin YP, Huang JY, Yang BC. Fas ligand enhances malignant behavior of tumor cells through interaction with Met, hepatocyte growth factor receptor, in lipid rafts. J Biol Chem. 2012 287 20664-73. 

Major tyrosine kinase receptor expressed in B16 melanoma cells. Synonyms hepatocyte growth factor receptor scatter factor receptor. Present in high-density protein fraction (Fr. 12). 

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