Epidermal growth factor receptor family targeting

Sartor CL Biological modifiers as potential radiosensitizers targeting the epidermal growth factor receptor family. Semin Oncol 2000 27(6 Suppl 11) 15-20. 

Receptor Tyrosine Kinases and Their Role in Malignancy Targeting the Epidermal Growth Factor Receptor Family Clinical Trials with Anti-HER-2 Strategies Clinical Trials Targeting the EGFR (HER-1)... 

TARGETING THE EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY... 

Bellmunt J, Hussain M, Dinney CP. Novel approaches with targeted therapies in bladder cancer. Therapy of bladder cancer by blockade of the epidermal growth factor receptor family. Crit Rev Oncol Hematol 2003 46(Suppl) S85. 

Kane, S. 2006. Cancer therapies targeted to the epidermal growth factor receptor and its family members. Expert Opinion on Therapeutic Patents 16(2), 147-164. 

The downstream targets of ceramide that are involved in apoptosis remain to be identified. A few potential targets have, however, been described. In A431 cells, Davis and co-workers showed that sphingomyelin induced phosphorylation of the epidermal growth factor receptor at a specific site, Thr 669 (Davis et al., 1988 Faucher et al., 1988 Countaway et al., 1989). This led to the description of a membrane-bound, Ca -independent protein kinase that is stimulated by ceramide (Mathias et al., 1991). Conversely, Hannun and co-workers have demonstrated that ceramide activates a member of the the heterotrimeric protein phosphatase 2A family in rat T9 glioma cells and have coined the term ceramide-activated protein phosphatase (CAPP) for this activity (Dobrowsky and Hannun,... 

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