Epidermal growth factor receptor EGER

There is a growing number of published examples of the utility of screening patients for pharmacogenetic markers prior to chemotherapy selection (1). Many published markers of association with chemotherapy outcome or toxicity still require validation in prospective studies. Examples of well-characterized pharmacogenetic markers include thiopurine methyltransferase (TPMT), UGT (uridine diphosphate [UDP]-glucuronosyltransferase) lAl, and epidermal growth factor receptor (EGER). 

A series of 6- and 7-aciylamide derivatives of 4-(phenylamino)-quinazoline and 4-(phenylainino)-pyridopyrimidine, classes of epidermal growth factor receptor (EGER) inhibitors, have been prepared from the corresponding amino compounds by reaction with actoyl chloride/base <99JMC1803>. Reaction of thionyl chloride with hexahydro-7-methyl-pyrimido[l,6-a]-pyrimidine-6,8-dione yields the corresponding 9,9 -thiobispyriiiudopyrimidine derivative <99JHC453>. 

S.-L. Wu, J. Kim, W.S. Hancock, B. Karger, Extended range proteomic analysis (ERPA) A new and sensitive LC-MS platform for high sequence coverage of complex proteins with extensive PTM-comprehensive analysis of beta-casein and epidermal growth factor receptor (EGER), J. Proteome Res., 4 (2005) 1155. 

Erlotinib (OSI-774, Epidermal growth factor receptor (EGER) tyrosine kinase Acneiform skin rash, diarrhea. Phase 1... 

Pednekar, D.V., Kelkar, M.A., Pimple, S.R. and Akamanchi, K.G. (2004) 3D QSAR studies of inhibitors of epidermal growth factor receptor (EGER) using CoMEA and GFA methodologies. Med. Chem. Res., 13, 605-618. 

CURCUMIN DOWN-REGULATES THE ACTIVITY OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGER) AND EXPRESSION OF HER2/NEU... 

Studies have demonstrated an overall response rate of 10%, whieh means 10% of the treated population will achieve a response. It is now known that essentially all of the people who respond to Iressa have a genetie mutation in the epidermal growth factor receptor (EGER) gene." Others have shown that the EGER mutation occurs most frequently in Japanese people and is relatively uneommon in Caucasians. Although, the positive clinical response rate to Iressa is relatively low, that... 

Tyrosine Kinases. They are enzymes that transfer a phosphate group from ATP to a tyrosine amino acid side chain of a protein. (De)phosphorylation is a major on/off-switch for a vast array of proteins and particularly interesting regarding cancer, as tyrosine kinases were found to be overexpressed in many solid mmors. Chemotherapeutics that target these enzymes are erlotinib, an epidermal growth factor receptor (EGER) inhibitor, and imatinib, which is also approved by... 

Polosa R, Krishna M, Howarth P, et al. Elevated epidermal growth factor receptor (EGER) expression in bronchial epithehum of mild and severe asthmatics (abstr). Bur Respir J 1998 12 265s. 

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