Epidermal growth factor receptor, cancer protection

Howe, L.R. et al., Celecoxib, a selective cyclooxygenase 2 inhibitor, protects against human epidermal growth factor receptor 2 (HER-2)/neu-induced breast cancer. Cancer Res., 62 (19),... 

Dent P, Reardon DB, Park JS, et al (1999) Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death. Mol Biol Cell 10 2493-2506 Eyier CE, Rich JN (2008) Survival of the fittest cancer stem cells in therapeutic resistance and angiogenesis. J Clin Oncol 26 2839-2845... 

Horton JK, Watson M, Stefanick DF, et al (2008) XRCCl and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks. Cell Res 18 48-63 Hutcheson IR, Knowlden JM, Jones HE, et al (2006) Inductive mechanisms limiting response to anti-epidermal growth factor receptor therapy. Endocr Relat Cancer 13(suppl 1) S89-S97... 

Whereas epidermal growth factor (EGF) enhances the radiosensitivity of human squamous ceU carcinoma cells in vitro (197), addition of EGF to hormone-deprived MCE-7 breast cancer cells prior to irradiation results ia iacreased radioresistance (198). An anti-EGE-receptor monoclonal antibody blocks the abiUty of EGE to enhance growth and radioresistance. Tumor cells, the growth of which is stimulated by EGE, appear to be protected those where growth is iohibited are sensitized (198). 

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