Lessons from

Brenner S E, C Chothia and T ] P Hubbard 1997. Population Statistics of Protein Structures Lessons from Structural Classifications. Current Opinion in Structural Biology 7 369-376. 

Cowan, S.W. Bacterial porins lessons from three high-resolution structures. Curr. Opin. Struct. Biol. 

Kletz, T.A. (1993) Lessons from Disasters How Organisations Have No Memory and Accidents Recur, Institutional Chemical Engineers, Rugby. 

The DOE and private industry have learned many lessons from years of experienee in site remediation. This book will refer to seleeted lessons learned from the DOE, the Army Corps of Engineers, private industry, and personal experienee. After reading this book the reader should have a better understanding of how to interpret the hazardous waste requirements to make sure eomplianee is maintained at a high level for eaeh site-speeifie aetivity. Over and above eomplianee, the authors eneourage the development of health and safety programs to help build a sound and workable safety eulture that ean be utilized aeross all boundaries. 

T. A. Kletz, Lessons From Disaster How Organizations Have No Memory and Accidents Recur, co-published by Institution of Chemical Engineers, Rugby, UK, and Gulf Publishing Co., Houston, Texas, 1993, Sections 2.2 and 8.10. 

The value of near miss reporting has been emphasized at a number of points in this book. Near misses represent an inexpensive way to learn lessons from... 

This indicates that error management comprises two strategies proactive methods are applied to prevent errors occurring, and reactive strategies are used to learn lessons from incidents that have occurred and to apply these lessons to the development of preventive measures. Both proactive and reactive methods rely on an understanding of the courses of human error based on the theories and perspectives presented in this book. The tools and tech-... 

Aurora, R., Creamer, T, Srinivasan, R., and Rose, G. D., 1997. Local interactions in protein folding Lessons from die ci-helix. TheJournal of Biological Chemistry 272 1413-1416. 

Of course, nowadays, as every student of chemistry and physics knows, electron orbits have been replaced by orbitals that are supposed to be smeared out in space. But this view misses the point somewhat and is not the whole lesson from quantum mechanics. The more radical lesson is that even these probability-based orbitals simply do not exist. The notion of assigning four quantum numbers to each electron is just an approximation, albeit a powerful one. 

Cotecchia S et al (2004) Structural determinants involved in the activation and regulation of G protein-coupled receptors lessons from the ai -adrenergic receptor sub-types. Biol Cell 96 327-333... 

Bell-Pedersen D, Cassone VM, Earnest DJ et al (2005) Circadian rhythms from multiple oscillators lessons from diverse organisms. Nat Rev Genet 6(7) 544-556... 

Akira S (1999) Functional roles of STAT family proteins lessons from knockout mice. Stem Cells 17 138-146... 

Blais Jr, Marceau F, Rouleau JL et al (2000) The kallikrein-kininogen-kinin system lessons from the quantification of endogenous kinins. Peptides 21 1903—1940... 

The main lesson from the analysis given above is that the activation free energy of the reaction is strongly correlated with the stabilization of the ionic resonance structure by the protein-active site. The generality of this concept will be considered in the following chapters. 

We have put this model into mathematical form. Although we have yet no quantitative predictions, a very general model has been formulated and is described in more detail in Appendix A. We have learned and applied here some lessons from Kilkson s work (17) on interfacial polycondensation although our problem is considerably more difficult, since phase separation occurs during the polymerization at some critical value of a sequence distribution parameter, and not at the start of the reaction. Quantitative results will be presented in a forthcoming pub1ication. 

On the structure and evolution of ENSO-related climate variability in the tropical Pacific Lessons from TOGA. /. Geophys. Res. 102, 14,241-14,259. 

The primary lesson from this example is that no process is infinitely scalable. Sooner or later, additional scaleup becomes impossible, and further increases in production cannot be single-train but must add units in parallel. Fortunately for the economics of the chemical industry, the limit is seldom reached. 

Cobb JA, Bjergbaek L (2006) RecQ heUcases lessons from model organisms. Nucleic Acids Res 34 4106 114... 

Sumpter, J.P. and Johnson, A.C. (2005). Lessons from endocrine disruption and their apphca-tion to other issues concerning trace organics in the aquatic environment. Environmental Science and Technology 39,4321 332. 

Finkelman FD Anaphylaxis lessons from mouse models. J Allergy Clin Immunol 2007 120 506-515. 

Foo CWP, Huang J, Kaplan DL (2004) Lessons from seashells silica mineralization via protein templating. Trends Biotechnol 22 577-585... 

Unfortunately, because of legal considerations, it is not possible to fully describe an implemented system within a specifically named company. However, in this section we address some key issues that have arisen within one of our recent projects with a major Pharma company, some of the lessons from which are, we feel, broadly applicable to future projects. 

Chen WW, Shakhnovich EE Lessons from the design of a novel atomic potential for protein folding. Protein Sci 2005 14 1741-52. 

Dinnett EM, Mungall MMB, Kent JA, Ronald ES, Gaw A. Closing out a large clinical trial lessons from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Clin Trials 2004 1.6 545-52. 

Burke D et al Fibroblast growth factor receptors lessons from the genes. Trends Biochem Sci 1998 23 59. 

According to the balanced equation, the synthesis of 2.0 moles of ammonia requires 3.0 moles of hydrogen and f.O mole of nitrogen. However, the balanced equation does not give us any direct information about the masses involved in the synthesis. One gram of N2 plus three grams of H2 does not make two grams of NH3. Remember the most important lesson from Chapter 3 ... 

Brew BJ, Halman M, Catalan J, Sacktor N, Price RW, Brown S, Atkinson H, Clifford DB, Simpson D, Torres G, Hall C, Power C, Marder K, Me Arthur JC, Symonds W, Romero C (2007) Factors in AIDS dementia complex trial design results and lessons from the abacavir trial. PLoS Clin Trials 2(3) el3... 

Joseph EK, Chen X et al (2004) Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat. Pain 107(1-2) 147-158 Jubelt B, Berger JR (2001) Does viral disease underlie ALS Lessons from the AIDS pandemic. Neurology 57(6) 945-946... 

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