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Epidermal growth factor receptor structure

Wissner A, Overbeek E, Reich MF et al. Synthesis and structure-activity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles. The design of an orally active, irreversible inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor-2 (ElER-2). JMed Chem 2003 46 49-63. [Pg.125]

Stamos, J., Sliwkowski, M. X., Eigenbrot, C. (2002) Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor. J Biol Chem 277(48), 46265-46272. [Pg.108]

K., Alligood, K. J., Rusnak, D. W., Gilmer, T. M., Shewchuk, L.. (2004) A unique structure for epidermal growth factor receptor bound to GW572016 (lapatinib) relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Cancer Res. 64, 6652-6659. [Pg.291]

D., Hassell, A., Dickerson, S. H., Ellis, B., et al. A Unique Structure for Epidermal Growth Factor Receptor Bound GW572016 (lapatinib) Relationships among Protein Conformation, Inhibitor Off-Rate, and Receptor Activity in Tumor Cells. Cancer Res. 2004,64, 6652-6659. [Pg.121]

Edwards, G. M., Defeo-Jones, D., Tai, J. Y., Vuocolo, G. A., Patrick, D. R., Heimbrook, D. C., and Oliff, A. (1989). Epidermal growth factor receptor binding is affected by structural determinants in the toxin domain of transforming growth factor-alpha-Psewdo-monas exotoxin fusion proteins. Mol. Cell. Biol. 9, 2860-2867. [Pg.70]

R2. Ravenna, L., Lubrano, C., Di Silverio, F., Vacca, A., Felli, M. P., etal., Androgenic and antian-drogenic control on epidermal growth factor, epidermal growth factor receptor, and androgen receptor expression in human prostate cancer cell line LNCaP. Prostate 26, 290—298 (1995). R3. Rechler, M. M., and Nissley, S. P., Insulin-like growth factor (IGF)/somatomedin receptor subtypes structure, function and relationships to insulin receptors and IGF carrier proteins. Horm. Res. 24, 152-159 (1986). [Pg.155]

Ward, W. H. J., Cook, P. N., Slater, A. M., Davies, D. H., Holdgate, G. A., Green, L. R. Epidermal growth factor receptor tyrosine kinase investigation of catalytic mechatusm, structure-based... [Pg.157]


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See also in sourсe #XX -- [ Pg.128 ]




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Epidermal structure

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