P75 Nerve Growth Factor receptor

Barrett GL, Bar tlett PF (1994) The p75 nerve growth factor receptor mediates survival or death depending on tire stage of sensory neuron development. Proc Natl Acad Sci USA 91 6501-6505. 

Sobreviela, T., Clary, D. O., Reichardt, L. F., Brandabur, M. M., Kordower, J. H., and Mufson, E. J., TrkA-immunoreactive profiles in the central nervous system colocalization with neurons containing p75 nerve growth factor receptor, choline acetyltrans-ferase, and serotonin, J. Comp. Neurol., 350, 587, 1994. 

P75 nerve growth factor-receptor protein (NGF-R) is present in developing and adult Purkinje cells. Yan and Johnson (1988) and Cohen-Cory et ah (1989) described and reviewed the development of NGF-R in rat cerebellum. Low affinity NGF-R immunoreactivity has been demonstrated with species-specific monoclonal antibodies in Purkinje cells of adult rats (Pioro and Cuello, 1988, 1990 Pioro et ah, 1991 Fusco et ah, 1991 Dusart et ah, 1994), monkey and human brain (Mufson et ah, 1991). Immunoreactivity was present in the somata, dendrites and the proximal axon of the Purkinje cells. Additional immunoreactivity in granule cells was reported by Vega et ah... 

Yoon, S.O., Casaccia-Bonnefd, P., Carter, B., Chao, M.V., 1998. Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival. J. Neurosci. 18, 3273-3281. 

The epitopes recognized by Hawkes family of monoclonal antibodies known as the anti-Zebrins are localized on Purkinje cells (see Section 3.1.8.). Zonal patterns that are identical or very similar to Zebrin I and II have been described for the distribution of 5 -nucleotidase (see above), the p75 low affinity nerve growth factor receptor protein in the rat (Section 3.1.10., Fig. 38), protein kinase C delta (Fig. 133) (see Section 3.1.5.) and the B30 antibody of Stainier and Gilbert (1989) (see Section 3.1.8.). Immunoreactiv-ity in mouse Purkinje cells for an antibody against HNK is partially congruent with the Zebrin negative Purkinje cells, but Zebrin+/HNK-l- Purkinje cells also exist (Hawkes, 1992 Eisenman and Hawkes, 1993). The similarity between the Zebrin pattern and the transient zonal patterns in the development of the Purkinje cell specific marker L7 is discussed in Section 6.2. 

Davidson B, Reich R, Lazarovici P, et al. Expression of the nerve growth factor receptor TrkA and p75 in malignant mesothelioma. Lung Cancer. 2004 44 159-165. 

Wyatt, S., Davies, A.M., 1993. Regulation of expression of mRNAs encoding the nerve growth factor receptors p75 and trkA mRNA in developing sensory neurons. Development 119, 635-647. 

Vroemen, M. Weidner, N. Purification of Schwann cells by selection of p75 low affinity nerve growth factor receptor expressing cells from adult peripheral nerve. J. Neurosci. Meth. 2003,124, 135. 

Cholinergic neurons in the basal forebrain and medial septum selectively express the low affinity (p75) receptor for nerve growth factor which allows them... 

FIGURE 2 7-2 Neurotrophin receptors. Neurotrophin family members bind specifically to cognate Trk receptors. The low affinity neurotrophin receptor, p75, promiscuously binds all neurotrophins. BDNF, brain-derived neurotrophic factor NGF, nerve growth factor NT, neurotrophin. 

Barrett GL, Georgiou A, Reid K, Bartlett PF, Leung D. 1998. Rescue of dorsal root sensory neurons by nerve growth factor and neurotrophin-3, but not brain-derived neurotrophic factor or neurotrophin-4, is dependent on the level of the p75 neurotrophin receptor. Neuroscience 85 1321-1328. 

The neurotrophin receptor p75 was first identified as a nerve growth factor (NGF)-binding protein and was subsequently shown to interact with each of the other neurotrophic factors, BDNF, neurotrophin-3, and neurotrophin-4/-5. It also modulates the activity of several members of the tropomyosin-related receptor tyrosine kinase family (Trk) (reviewed in Chao, 2003). p75, a member of the tumor necrosis factor superfamily, is a type I transmembrane protein with four cysteine-rich domains in its extracellular region and a Death domain in its cytoplasmic protein (Fig. 11). 

B. D. Carter, C. Kaltschmidt, B. Kaltschmidt, N. Ofienhauser, R. Bohm Matthaei, P. A. Baeuerle and Y. A. Barde. Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75 [see comments]. Science, 272 (5261), 542-545, 1996. 

Casaccia-Bonnefil, P., Carter, B. D., Dobrowsky, R. T., and Chao, M. V., Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75, Nature, 383, 716, 1996. 

Frade, J.M., Rodriguez-Tebar, A., Barde, Y.-A., 1996. Induction of cell death by endogenous nerve growth factor through its p75 receptor. Nature 383, 166-168. 

Gargano, N., Levi, A., Alema, S., 1997. Modulation of nerve growth factor internalization by direct interaction between p75 and TrkA receptors. J. Neurosci. Res. 50, 1-12. 

In addition, neurotrophins bind to a distinct receptor called p75 either alone or in combination withTrks. NGF = nerve growth factor BDNF = brain-derived neurotrophic factor ... 

Apoptosis mediated by p75 requires specific conditions, with regard to cell type, cell cycle stage, developmental stage, injury or stress. This could be due to time in culture, metabolic impairment, hypoxia, or other types of stress signals, such as nerve injury or trauma (Gu et al., 1999). Sensitive cells may be highly susceptible to injury and inflammation and may become more reactive to released growth factors and cytokines by upregulating receptor expression at the site of injury. 

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