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Platelet-derived growth factor receptors

Platelet-activating Factor Platelet Aggregation Inhibitors Platelet-derived Growth Factor Receptor Platelet Inhibitors Platelets... [Pg.1500]

PDGFR Platelet-derived growth factor receptor... [Pg.285]

Board, R. and Jayson, G. 2005. Platelet-derived growth factor receptor (PDGFR) a target for anti cancer therapeutics. Drug Resistance Updates 8(1-2), 75-83. [Pg.289]

PDGFR platelet-derived growth factor receptor RAGS repulsive axon guidance signal... [Pg.966]

Fig. 2. Presentation of the intracellular domain of the PDGF (platelet-derived growth factor) receptor. The two catalytically active kinase domains are highlighted. Docking sites for SH2 domains are symbolized with a pTyr sidechain. SH2 domains identified to bind to the corresponding phosphorylated tyrosines (numbered on the left) are schematically depicted and labeled on the right... Fig. 2. Presentation of the intracellular domain of the PDGF (platelet-derived growth factor) receptor. The two catalytically active kinase domains are highlighted. Docking sites for SH2 domains are symbolized with a pTyr sidechain. SH2 domains identified to bind to the corresponding phosphorylated tyrosines (numbered on the left) are schematically depicted and labeled on the right...
Effect on PDCPpR and on Platelet Derived Growth Factor Receptor P Tyrosine Phosphorylation... [Pg.196]

Miyake, S., M. L. Lupher, Jr., B. Druker, and H. Band. The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha. Proc Natl Acad Sci USA. 95 7927-7932.1998. [Pg.134]

Miyake, S., K. P. Mullane-Robinson, N. L. Lill, P. Douillard, and H. Band. Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain. J Biol Chem. 274 16619-28.1999. [Pg.134]

Claesson-Welsh, L. (1994). Platelet-derived growth factor receptor signals. J. Biol. Chem. 269(51), 32023-32026. Downward, J. et al. (1984). Close similarity of EGF receptor and V-erb-B oncogene protein sequences. Nature 307, 521-527. [Pg.300]

Hu P, Margolis B, Skolnik EY et al. Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors. Mo/ Cell Biol 1992 12 981-990. Li N, Batzer A, Daly R et al. Guanine-nucleotide-releasing factor hSosl binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature 1993 363 85-88. [Pg.122]

Domin, J. Dhand, R. Waterfield, M.D. Binding to the platelet-derived growth factor receptor transiently activates the p85a-pll0a phosphoinositide 3-kinase complex in vivo. J. Biol. Chem., 271, 21614-21621 (1996)... [Pg.184]

Imatinib (STI571) is an inhibitor of the tyrosine kinase domain of the Bcr-Abl oncoprotein and prevents the phosphorylation of the kinase substrate by ATP. It is indicated for the treatment of chronic myelogenous leukemia (CML), a pluripotent hematopoietic stem cell disorder characterized by the t(9 22) Philadelphia chromosomal translocation. This translocation results in the Bcr-Abl fusion protein, the causative agent in CML, and is present in up to 95% of patients with this disease. This agent inhibits other activated receptor tyrosine kinases for platelet-derived growth factor receptor (PDGFR), stem cell factor (SCF), and c-kit. [Pg.1307]

L. Wong, G. Yamasaki, R. J. Johnson, and S. L. Friedman, Induction of P-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture, J. Clin. Invest. 94 1563-1569 (1994). [Pg.233]

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Growth factors receptors

Growth receptor

Platelet-derived growth factor PDGF) receptor

Platelet-derived growth factor beta receptor

Platelet-derived growth factor receptor PDGFR)

Platelet-derived growth factor receptor kinase

Platelet-derived growth factor receptor tyrosine

Platelet-derived growth factor receptor tyrosine kinase inhibition

Platelets receptors

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