Epidermal growth factor receptor oncogenes

Deoxycholic acid has also been demonstrated to activate other pivotal oncogenic pathways in CRC cells in vitro including p-catenin/T-cell factor-mediated transcription, extra-cellular signal-regulated kinase activation downstream of the epidermal growth factor receptor and Jun-N-terminal kinase... 

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Meisner, H., and M. P. Czech. Coupling of the proto-oncogene product c-Cbl to the epidermal growth factor receptor. J Biol Chem. 270 25332-25335.1995. 

Sorkin, A., P. P. Di Fiore, and G. Carpenter. The carboxyl terminus of epidermal growth factor receptor/erbB-2 chimerae is internalization impaired. Oncogene. 8 3021-3028.1993. 

Montgomery RB, Guzman J, O Rourke DM, Stahl WL. Expression of oncogenic epidermal growth factor receptor family kinases induces paclitaxel resistance and alters beta-tubulin isotype expression. J Biol Chem 2000 275 17,358-17,363. 

In comparison to the level of cellular serine or threonine phosphorylation, protein tyrosine phosphorylation occurs at quite low levels in normal cells but dramatically increases upon oncogenic transformation or stimulation. Since the first discovery in 1978 that the transforming protein from Rous sarcoma virus (pp60vsrc) exhibited intrinsic kinase activity/5 protein kinase activity has also been shown to be inherent to other growth factor receptors such as epidermal growth factor receptor and the insulin receptor,[6 91 and to involve autophosphorylation processes. The diverse biochemical activity exhibited by protein tyrosine phosphorylation has stimulated the development of chemical methods for the preparation of phosphorylated peptides for use as substrates in elucidating the biochemical and physiological activity of phosphorylated site(s). 

Chen A, Xu J, Johnson AC. 2006. Curcumin inhibits human colon cancer cell growth by suppressing gene expression of epidermal growth factor receptor through reducing the activity of the transcription factor Egr-1. Oncogene 25 278-287. 

Bargmann, G. I., Hung, M. C., and Weinberg, R. A. (1986b). The neu oncogene encodes an epidermal growth factor receptor-related protein. Nature 226-230. 

Downward, J., Yarden, Y, Mayes, E., Scrace, G., Totty, N., Stockwell, P., Ullrich, A., Schlessinger, J., and Waterfield, M. D. (1984). Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature 307, 521-527. 

The signaling molecules that are downregulated by the Cbl proteins include receptor tyrosine kinases like the epidermal growth factor receptor (EGFR, see Chapter 8) and nonreceptor tyrosine kinases like Zap 70 (see Section 11.3). The central importance of the Cbl proteins for cellular regulation is highlighted by the observation that oncogenic forms of Cbl have been found in mouse retroviruses. 

Gschwind, A., Zwick, E., Prenzel, N., Lese-rer, M. and Ullrich, A. (2001) Cell communication networks epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission. Oncogene, 20, 1594-1600. 

Bheda A, Creek KE, Pirisi L. Loss of p53 induces epidermal growth factor receptor promoter activity in normal human keratinocytes. Oncogene. 2008 27 4315-23. 

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