Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Extracellular growth factor receptor EGFR

Bevacizumab, a humanized IgG and cetuximab, a chimeric IgGx, are currently marketed in the US for treatment of metastatic colorectal cancer [92, 93]. Bevacizumab neutralizes the biological activity of vascular endothelial growth factor (VEGF), while cetuximab binds specifically to the extracellular domain of the human epidermal growth factor receptor (EGFR). Bevacizumab, in combination with IV 5-fluorouracil (5-FU) -based chemotherapy, is indicated for first-line treatment of metastatic colorectal cancer, whereas cetuximab is used in patients refractory to or intolerant to irinotecan-based chemotherapy. The clinical pharmacokinetics of cetuximab are discussed in detail in Chapter 14. [Pg.318]

EGFR Epidermal growth factor receptor ERK Extracellular signal-regulated kinase GSH Glutathione... [Pg.203]

See other pages where Extracellular growth factor receptor EGFR is mentioned: [Pg.98]    [Pg.98]    [Pg.338]    [Pg.240]    [Pg.79]    [Pg.179]    [Pg.419]    [Pg.530]    [Pg.168]    [Pg.117]    [Pg.281]    [Pg.353]    [Pg.75]    [Pg.266]    [Pg.522]    [Pg.438]    [Pg.401]    [Pg.150]    [Pg.120]    [Pg.1277]    [Pg.213]    [Pg.214]    [Pg.266]    [Pg.746]    [Pg.478]    [Pg.598]    [Pg.388]    [Pg.192]    [Pg.211]    [Pg.228]    [Pg.95]    [Pg.106]    [Pg.3]    [Pg.99]    [Pg.188]    [Pg.148]    [Pg.3]    [Pg.95]    [Pg.459]    [Pg.404]    [Pg.94]    [Pg.194]    [Pg.65]    [Pg.17]    [Pg.108]    [Pg.569]   
See also in sourсe #XX -- [ Pg.98 ]



SEARCH



EGFR

Growth factors receptors

Growth receptor

© 2024 chempedia.info