Platelet-derived growth factor beta receptor

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Mori, S., C. H. Heldin, and L. Claesson-Welsh. Ligand-induced polyubiquitination of the platelet-derived growth factor beta-receptor. J Biol Chem. 267 6429-34.1992. 

Mori, S., H. Kanaki, K. Tanaka, N. Morisaki, and Y. Saito. Ligand-activated platelet-derived growth factor beta-receptor is degraded through proteasome-dependent proteolytic pathway. Biochem Biophys Res Commun. 217 224-9.1995a. 

Heeneman S, Haendeler J, Saito Y, Ishida M, Berk BC. 2000. Angiotensin II induces transactivation of two different populations of the platelet-derived growth factor beta receptor. Key role for the p66 adaptor protein She. J Biol Chem 275 15926-15932. 

Tanimoto, T., Lungu, A. O., et al. (2004). Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells. Circ Res 94(8) 1050-8. Epub 2004 Mar 25. 

Gozal D, Simakajomboon N, Czapla MA, Xue YD, Gozal E, Vlasic Y, Lasky JA, Liu JY. Brainstem activation of platelet-derived growth factor-beta receptor modulates the late phase of the h q)oxic ventilatory response. J Neurochem 2000 74 310-319. 

Yoshida M, Sakuma-Mochizuki J, Abe K, Arai T, Mori M, Goya S, Matsuoka H, Hayashi S, Kaneda Y, Kishimoto T. In vivo gerte transfer of an extracellular domain of platelet-derived growth factor beta receptor by the HVJ-liposome method ameliorates bleomycin-induced pulmonary fibrosis Biochem Biophys Res Commun 1999 265 503-508. 

Other kinase receptors are serine/threonine kinases, protein kinases, and mitogen-activated protein (MAP) kinases. Insulin, transforming growth factor-beta (TGF- 8), and platelet-derived growth factor (PDGF) are the natural ligands that interact with kinase receptors. 

Gao BB, Hansen H, Chen HC, Feener EP. 2006. Angiotensin II stimulates phosphorylation of an ectodomain-truncated platelet-derived growth factor receptor-beta and its binding to class IA PI3K in vascular smooth muscle cells. Biochem J 397 337-344. 

Jarvius, M., Paulsson, J., Weibrecht, I., Leuchotvius, K. J., Andersson, A. C., Wahlby, C., et al. (2007). In situ detection of phosphorylated platelet-derived growth factor receptor beta using a generalized proximity ligation method. Alolecular Cellular Proteomics, 6(9), 1500—1509. http //dx.doi.Org/10.1074/mcp.M700166-MCP200. 

Abrams, T.J., Lee, L.B., Murray, L.J., Pryer, N.K., Cherrington, J.M. SU11248 inhibits KIT and platelet-derived growth factor receptor beta in precUnical models of human small cell lung cancer. Molecular Cancer Therapeutics 2(5), 471- 78 (2003)... 

Figure 5. Crosstalk mechanisms involving sphingosine 1-phosphate (SIP) or lysophosphatidic acid (LPA). GRK2, G-protein coupled receptor kinase 2. PDGF, platelet-derived growth factor. PDGFR, platelet-derived growth factor receptor. SIP, sphingosine 1-phosphate receptor 1. MAPK, mitogen-activated protein kinase, a., alpha subunit of the heterotrimeric inhibitory G-protein, G.. py, beta/gamma subunits of a heterotrimeric G-protein.

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