Cell migration

A similar result is also indentified in a study on invasion of prostate cancer cells in the HA hydrogel, showing that the gel triggers the cells to express and localise the receptors for HA-mediated motility by interacting with the HA hydrogel components [53]. Hence, the gel scaffold made from HA may keep this function and contribute to the cellular migration. 

On the other hand, some modification of the HA hydrogel may also promote the migration, as showed in research on mouse MSC, which 

Different modifications to the gels also affect NSC differentiation. For example. Pan and co-workers [50] have found that the NSC differentiate into fewer neuronal cells on the HA-PLL hydrogel, compared with more such cells on the hydrogels of HA, or HA with NgR antibody. 

It can be concluded therefore, that different HA hydrogels should be good materials for regulating the fate of NSC, indicating they have bright prospects for applications in NSC and tissue engineering for neural restoration. 

Picard-Riera, B. Nait-Oumesmar and A. Baron-Van Evtrcoortn, Journal of Neuroscience Research, 2004, 76, 223. 

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TNP470 Analog of fumagillin, inhibits cell migration and proliferation... 

The calcification of atherosclerotic plaques may be induced by osteopontin expression, since osteopontin is a protein with a well-characterized role in bone formation and calcification. Vascular smooth muscle cell migration on osteopontin is dq endent on the integrin av 33 and antagonists of av 33 prevent both smooth muscle cell migration and restenosis in some animal model [8]. 

Franco SJ, Huttenlocher A (2005) Regulating cell migration calpains make the cut. J Cell Sci 118 3829-3838... 

Ras is a G protein that cycle between two conformations, an activated Ras-GTP or inactivated form Ras-GDP. Ras, attached to the cell membrane by lipidation, is a key component in many signalling cascades, which couple growth factor receptors to downstream effectors that control such processes as cytoskeletal integrity, proliferation, cell adhesion, apoptosis and cell migration. Mutations and dysregulations of the Ras protein leading to increased invasion and metastasis, and decreased apoptosis are very common in cancers. 

Transforming growth factor-beta (TGF- 3) proteins are multifunctional morphogens that control cell proliferation, differentiation and apoptosis, as well as cell migration and immune surveillance. TGF-(3 acts as a tumor suppressor, but can also act as a tumor promoter in... 

Cell migration and cytoplasmic movement involve predominantly actin filaments in the locomotion of neutrophilic granulocytes, both actin filaments and microtubules in the elongation of neuronal growth cones and migration of neurites, and both actin and myosin in cytokinesis and the contraction of skeletal and cardiac muscle. 

Chu, Y-W., Runyan, R.B., Oshima, R.G., Hendrix, M.J.C. (1993). Expression of complete keratin filaments in mouse L cells augments cell migration and invasion. Proc. Natl. Acad. Sci. USA 90, 4261-4265. 

Fig. 4. Regulatory T-cell functions suppression of DCs that support the generation of effector T cells suppression of ThI, Th2, and ThI 7 cells suppression of allergen-specific IgE and induction of lgG4, IgA, or both suppression of mast cells, basophils, and eosinophils interaction with resident tissue cells and remodeling, and suppression of effectorT-cell migration to tissues. 

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