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Breast tumors epidermal growth factor receptor

Trastuzumab is a recombinant DNA-derived, humanized monoclonal antibody that binds to the extracellular domain of the human epidermal growth factor receptor HER-2/ . This antibody blocks the natural ligand from binding and down-regulates the receptor. Trastuzumab is approved for the treatment of metastatic breast cancer in patients whose tumors overexpress HER-2/ . As a single agent it induces remission in about 15-20% of patients in combination with chemotherapy, it increases response rate and duration as well as 1-year survival. Trastuzumab is under investigation for other tumors that express HER-2... [Pg.1197]

Zhang DH, Tai LK, Wong LL, Sethi SK, Koay ES. Proteomics of breast cancer Enhanced expression of cytokeratinl9 in human epidermal growth factor receptor type 2 positive breast tumors. Proteomics 2005 5(7) 1797-1805. [Pg.134]

Kersting C, Kuijper A, Schmidt H, et al. Amplifications of the epidermal growth factor receptor gene (egfr) are common in phyllodes tumors of the breast and are associated with tumor progression. Lab Invest. 2006 86 54-61. [Pg.815]

Tse GM, Lui PG, Vong JS, et al. Increased epidermal growth factor receptor (EGFR) expression in malignant mammary phyllodes tumors. Breast Cancer Res Treat. 2009 114 441-448. [Pg.815]

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Breast tumors

Epidermal

Epidermal growth factor

Epidermal growth factor , receptor

Epidermal tumors

Growth factors receptors

Growth receptor

Tumor growth

Tumor growth factor

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