Epidermal growth factor receptor transactivation

Eguchi, S., Numaguchi, K., Iwasaki, H., et al. 1998. Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells. J Biol Chem 273 8890-8896. 

Ohtsu, H., Dempsey, P. J., Frank, G. D., et al. 2006. ADAM17 mediates epidermal growth factor receptor transactivation and vascular smooth muscle cell hypertrophy induced by angiotensin II. Arterioscler Thromb Vase Biol 26 el33-137. 

Ushio-Fukai, M., Griendling, K. K., Becker, P. L., et al. 2001. Epidermal growth factor receptor transactivation by angiotensin II requires reactive oxygen species in vascular smooth muscle cells. Arterioscler Thromb Vase Biol 21 489—495. 

Wang, D., Yu, X., and Brecher, P. 1999. Nitric oxide inhibits angiotensin II-induced activation of the calcium-sensitive tyrosine kinase proline-rich tyrosine kinase 2 without affecting epidermal growth factor receptor transactivation. J. Biol. Chem. 274 24342-24348. 

Zhai, P., Galeotti, J., Liu, J., Holle, E., Yu, X., Wagner, T., and Sadoshima, J. 2006. An angiotensin II type 1 receptor mutant lacking epidermal growth factor receptor transactivation does not induce angiotensin Il-mediated cardiac hypertrophy. Circ. Res. 99 528-536. 

Lucchesi PA, Sabri A, Belmadani S, Matrougui K. 2004. Involvement of metalloproteinases 2/9 in epidermal growth factor receptor transactivation in pressure-induced myogenic tone in mouse mesenteric resistance arteries. Circulation 110 3587-3593. 

Meng D, Shi X, Jiang BH, Fang J. 2007. Insulin-like growth factor-I (IGF-I) induces epidermal growth factor receptor transactivation and cell proliferation through reactive oxygen species. Free Radio Biol Med 42 1651-1660. 

Ohtsu H, Dempsey PJ, Frank GD, Brailoiu E, Higuchi S, Suzuki H, Nakashima H, Eguchi K, Eguchi S. 2006b. ADAM17 mediates epidermal growth factor receptor transactivation and... 

Gschwind, A., Zwick, E., Prenzel, N., Lese-rer, M. and Ullrich, A. (2001) Cell communication networks epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission. Oncogene, 20, 1594-1600. 

Porcile C., Bajetto A., Barbero S., et al. (2004) CXCR4 activation induces epidermal growth factor receptor transactivation in an ovarian cancer cell line. Ann N Y Acad Sci., 1030, 162-9. 

Leserer, M., Gschwind, A., and Ullrich, A. 2000. Epidermal growth factor receptor signal transactivation. IUBMB Life 49(5), 405-430. 

Filardo EJ (2002) Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30 a novel signaling pathway with potential significance for breast cancer. J Steroid Biochem Mol Biol 80 231... 

Iwasaki H, Eguchi S, Marumo F, Hirata Y. 1998. Endothelin-1 stimulates DNA synthesis of vascular smooth-muscle cells through transactivation of epidermal growth factor receptor. J Cardio-vasc Pharmacol 31 Suppl 1 S182-S184. 

Kawanabe Y, Masaki T, Hashimoto N. 2004. Involvement of epidermal growth factor receptor-protein tyrosine kinase transactivation in endothelin-1-induced vascular contraction. J Neuro-surg 100 1066-1071. 

Moriguchi Y, Matsubara H, Mori Y, Murasawa S, Masaki H, Maruyama K, Tsutsumi Y, Shibasaki Y, Tanaka Y, Nakajima T, Oda K, Iwasaka T. 1999. Angiotensin Il-induced transactivation of epidermal growth factor receptor regulates fibronectin and transforming growth factor-beta synthesis via transcriptional and posttranscriptional mechanisms. Circ Res 84 1073-1084. 

Zhuang S, Yan Y, Han J, and Schnellmann RG. p38 kinase-mediated transactivation ofthe epidermal growth factor receptor is required for dedifferentiation of renal epithelial cells after oxidant injury.The Journal of Biological Chemistry 280 21036-21042, 2005. 

Multiple mechanisms are probably involved in immune-modulating effects of AMPs. A variety of receptors has been described for cathelicidins, however, only one biological function, that of LL-37-mediated chemotaxis of human peripheral blood leukocytes, is associated with a known receptor (formyl peptide receptor like 1), [187]. Human BD-2 recruits mast cells and LL-37 activates epithelial cells through at least 2 classes of receptors [183,202], LL-37 transactivates epidermal growth factor receptor (EGFR) and promotes the release of IL-ip [203], and LL-37-induced maturation of LPS-primed monocytes requires the P2X(7)... 

Tanimoto, T., Lungu, A. O., et al. (2004). Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells. Circ Res 94(8) 1050-8. Epub 2004 Mar 25. 

Buteau J, Foisy S, Joly E, Prentki M. Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor. Diabetes 2003 52 124-132. 

LPA can transactivate the epidermal growth factor receptor (EGFR), i.e. induce the tyrosine phosphorylation and activation of EGFR in the absence of EGF addition (Daub et al, 1996). This occurs due to the autocrine or paracrine action of heparin-binding EGF (an EGF receptor ligand) that is constitutively shed in the presence of LPA (Hirata et al., 2001). However, LPA-stimulated p42/p44 MAPK activation can also occur entirely independently of the EGF receptor (Andreev et al, 2001). 

Yan, E, Liu, L., Dempsey, P.J., et al. (2013) A Lactobacillus rhamnosus GG-derived soluble protein, p40, stimulates ligand release from intestinal epithelial cells to transactivate epidermal growth factor receptor. J Biol Chem 288, 30742-30751. 

TP receptor signaling has been extensively docnmented in vascnlar smooth mns-cle and platelets, but its characterization in hnman ASM cells has been more limited until recently. ASM cells express messenger RNA (mRNA) for both TP receptor isoforms, and functional receptors respond to agonist with an increase in intracellular Ca " concentration (200). As a consequence, besides potentiating the epidermal growth factor (EGF) mitogenic response independently from transactivation of the EGF receptor (EGER) (200), TP receptor stimulation induces a concentration-dependent increase in DNA synthesis. 

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