Growth factor receptor-bound protein

HSP27 Growth factor receptor-bound protein 2... 

Fig. 3. A simplified illustration of BCR-ABL and SRC family kinase involvement in oncogenic signaling pathways. The inhibitory effect is indicated by the upside-down T s. ABL = Abelson tyrosine kinase BCR = breakpoint cluster region FAK = focal adhesion kinase Grb-2 = growth factor receptor-bound protein 2 HcK = hematopoietic cell kinase JNK = Jun amino-terminal kinase P = phosphate group PI3 K = phosphatidylinositol-3-kinase SFK = SRC family kinases StatS = signal transducer and activator of transcription 5. (Reprinted with permission from Ref (123)). 

Fig. 15.1. Signal pathways activated or inhibited by BCR-ABL oncoprotein. The figure shows some of all the downstream signalling pathways of BCR-ABL note, more molecules which interact with BCR-ABL have been reported. GRB2, growth factor receptor-bound protein 2 PI3K, phosphatidylinositol 3-kinase ICSBP, interferon consensus sequence binding protein.

Grb2 Growth factor receptor-bound protein 2, an adaptor protein involved in signal transduction/cell... 

Growth factor receptor bound protein 2 409816 increased association of iRS-1/phosphatidyiinositoi 3-kinase, iRS-1/growth factor receptor bound 2 (Grb2), and Shc/Grb2 in diabetic rats [96]... 

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