Liposomes growth factor receptor

Drummond DC, Marx C, Guo Z, et al. Enhanced pharmacodynamic and antitumor properties of a histone deacetylase inhibitor encapsulated in liposomes or ErbB2-targeted immunoliposomes. Clin Cancer Res 2005 11 3392-3401. Mamot C, Drummond Dc, Noble CO, et al. Epledermal growth factor receptor-targeted immunoliposomes significantly enhance the efficacy of multiple anticancer drugsin vivo. Cancer Res 2005 65 1631-1638. 

Rosenberg, M.B., X.O. Breakefield, and E. Hawrot, Targeting of liposomes to cells bearing nerve growth factor receptors mediated by biotinylated nerve growth factor. J Neurochem, 1987. 48(3) 865-75. 

Drummond DC et al (2000) Liposome targeting to tumors using vitamin and growth factor receptors. Vitam Horm 60 285-332... 

The search for new ligands for liposome targeting concentrates around specific receptors overexpressed on target cells (particularly cancer cells) and certain specific components of pathologic cells. Thus, liposome targeting to tumors has been achieved by using vitamin and growth factor receptors. ... 

Antibodies against the human epidermal growth factor receptor 2 (HER2) have been widely used in combination with liposomal drug delivery systems. This antigen is frequently overexpressed on various types of cancer cells and is only weakly expressed in normal tissues. One of the first studies of investigating Fab ... 

Wang, S. et al. Delivery of antisense oKgodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol, Proc. Natl Acad. Sci. USA, 92, 3318,1995. 

Epidermal Growth Factor Receptor-Targeted Liposomes... 

An increase in therapeutic efficacy and lower toxicity was reported with liposomes where the bradykinin analogue RMP-7 was chemically attached at the end of PEG molecules of PEGylated liposomes (approximate size 70nm) [384], RMP-7 exhibits high selectivity for the B2 receptor of the BBB endothelial cells, which shrunk and let the RMP-7-PEG liposomes to pass into the brain. Actually the mechanism used in that study was based on opening the tight junctions of the BBB. Liposome-incorporated nerve growth factor (NGF) concentration increased 10 times in comparison to free NGF, while they accumulated mainly in striatum, hippocampus, and cortex. 

Yoshida M, Sakuma-Mochizuki J, Abe K, Arai T, Mori M, Goya S, Matsuoka H, Hayashi S, Kaneda Y, Kishimoto T. In vivo gerte transfer of an extracellular domain of platelet-derived growth factor beta receptor by the HVJ-liposome method ameliorates bleomycin-induced pulmonary fibrosis Biochem Biophys Res Commun 1999 265 503-508. 

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