Insulin-like growth factor 1 receptor IGF

Focal adhesion kinase (FAK) is a non-ieceptor cytoplasmic tyrosine kinase that plays an important role in several different cell processes inclnding cell proliferation, migration, and survival [1]. Importantly, FAK is overexpressed in cancers and inhibition of FAK activity sensitizes cancer cells to apoptosis [2], suggesting that FAK plays a role in carcinogenesis. Very recen%, Liu et al have shown that FAK and insulin-like growth factor 1 receptor (IGF-IR) interact to provide survival... 

IGF-l-RTK, insulin-like growth factor-1 receptor tyrosine kinase IGF-2, insulin-like growth factor-2 IGF-2-RTK, insulin-like growth factor-2 receptor tyrosine kinase iGlu-R, inhibitory glutamate receptor IKK, inhibitor kB kinase IL, interleukin IL-1P, interleukin-1P IL-ip-R, interleukin-ip receptor IL-1, interleukin-1 IL-8, interleukin-8 IL-8-R, interleukin-8-receptor lie, isoleucine Im, imidazole... 

Attias-Geva Z, Bentov I, Ludwig DL, Fishman A, Bruchim 1, Werner H. Insulin-like growth factor-I receptor (IGF-IR) targeting with monoclonal antibody cixutumumab (IMC-A12) inhibits IGF-I action in endometrial cancer cells. Eur J Cancer. 2011 47 1717-26. 

Insulin-like growth factor 1 receptor/kinase (IGF-1R/IGFR)... 

Kanagaraj, P, MR Vijayababu, B Ravisankar, J Anbalagan, MM Aruldhas, and J Aranakaran. 2007. Effect of lycopene on insulin-like growth factor-1, IGF binding protein-3, and IGF type-1 receptor in prostate cancer cells. 7 Cancer Res Clin Oncol 133 351-359. 

Insulin-like growth factor-1 (IGF-1) is a peptide, 7649 Da, with structural homology to proinsulin. It binds preferentially to IGF-1 receptors on the surface of target cells. It has a lower affinity for insulin receptors. The receptors for insulin and IGF-1 share some structural and functional homology. IGF-1 is produced in the liver and in other organs in response to growth hormone action. IGF-1 that reenters the circulation is bound to... 

Growth hormone requires mediation by somatomedins for many of its actions. These are chiefly formed in the liver, including the important somatomedin C (= insulin-like growth factor 1, IGF-1). Pegvisomant is a newly developed antagonist at the GH receptor and inhibits the production of IGF-1. 

The anterior pituitary releases GH in 6 to 8 pulsatile bursts over a 24 h period the major portion is released just prior to deep sleep. Its secretion is controlled by hypothalamic peptides GH-releasing hormone stimulates GH secretion, while somatostatin inhibits it. GH stimulates the synthesis of insulin-like growth factor-1 (IGF-1 somatomedin C) mainly, but not solely, in the liver. GH and IGF-1 receptors are widely scattered throughout the body, and both hormones exert important metabolic actions in various tissues, especially muscle and bone. 

IGF-RTK, insulin-like growth factor receptor tyrosine kinase IGF-1, insulin-like growth factor-1... 

IGF-1 Insulin-like growth factor-1, also called somatomedin C a 70-amino acid peptide that shares structural homology with proinsulin. IGF-1 is synthesized and released by the hver in response to growth hormone binding to receptors on the hepatocyte. 

Bondy, C.A., Werner, H., Roberts, C.T., Jr. and LeRoith, D. (1990) Cellular pattern of insulin-like growth factor-1 (IGF-I) and type I IGF receptor gene expression in early organogenesis comparison with IGF-II gene expression. Mol. Endocrinol. 4 1386-1398. 

Toilet, P., B. Enberg, and A. Mode (1990). Growth hormone (GH) regulation of cytochrome P-45011C12, insulin-like growth factor-1 (lGF-1), and GH receptor messenger RNA expression in primary rat hepatocytes A hormonal interplay with insulin, IGF-1, and thyroid hormone. Mol. Endocrinol. 4, 1934-1942. 

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