Epidermal growth factor receptors model

Gadella, T. W. J. and Jovin, T. M. (1995). Oligomerization of epidermal growth-factor receptors on A431 cells studied by time-resolved fluorescence imaging microscopy—a stereochemical model for tyrosine kinase receptor activation. J. Cell Biol. 129, 1543-58. 

Goldstein NI, Prewett M, Zuklys K, et al. Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model. Clin Cancer Res 1995 1 1311— 1318. 

Resat H, Ewald JA, Dixon DA, Wiley HS. An integrated model 93. of epidermal growth factor receptor trafficking and signal transduction. Biophys. J. 2003 85 730-743. 94. 

Model I has been applied to a wide variety of drug responses, such as the reduction of fever (8, 20) or pain (19) by anti-inflammatory drugs, anticoagulant action of warfarin (3,9), reduction in blood sorbitol levels by inhibitors of aldose reductase (21), cortisol suppressive effects of corticosteroids (22), luteinizing hormone suppression by the synthetic hormone cetrorelix (23), reduction in the levels of tumoral phospho-EGFR (epidermal growth factor receptor) by cetuximab (24), inhibition of dihydrotestosterone (25), the suppression of T-lymphocyte influx into the blood by corticosteroids (26), and the acid-inhibitory effects of H2-receptor antagonists (27). 

Jan YY, Yeh TS, Yeh JN, et al. Expression of epidermal growth factor receptor, apomucins, matrix metalloproteinases, and p53 in rat and human cholangiocarcinoma appraisal of an animal model of cholangiocarcinoma. Ann Surg. 2004 240 89-94. 

Meenakshi A, Ganesh V, Suresh Kumar R et al (2003) Radioimmuno targetting technetium-labeled anti-epidermal growth factor receptor monoclonal antibodies in experimental tumor models. Q J Nucl Med 47 139-144... 

C. Starbuck, D.A. Lauffenburger, Mathematical model for the effects of epidermal growth factor receptor trafficking dynamics on fibroblast proliferation responses, Biotechnol. Prog. 1992, 8, 132-143. 

Yarden, Y. and Schlessinger, J., Self-phosphorylation of epidermal growth factor receptor evidence for a model of mtermolecular allosteric activation. Biochemistry, 26, 1434, 1987. 

Williams KJ et al (2002) ZD1839 ( Iressa ), a specific oral epidermal growth factor receptor-tyrosine kinase inhibitor, potentiates radiotherapy in a human colorectal cancer xenograft model. Br J Cancer 86 1157-1161... 

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