Transforming growth factor P receptor

Davies, S.J., Shoemaker, C.B. and Pearce, E.J. (1 998) A divergent member of the transforming growth factor-p receptor family from Schistosoma mansoni is expressed on the parasite surface membrane. The journal of Biological Chemistry 273, 1 1234-1 1240. 

Goodman LV, Majack RA (1989) Vascular smooth muscle cells express distinct transforming growth factor-P receptor phenotypes as a function of cell density in culture. J Biol Chem 264 5241-5244... 

Thiadiazoles are incorporated into the allosteric inhibitor ofPRMT3 (protein arginine methyltransferase 3) 163 (13JMC2110), and inhibitor of TAKl (transforming growth factor p receptor-associated kinase 1) 164 (13BMCL4517). 

Hyperphosphorylation of ERAK-1 by itself and ERAK-4 causes ERAK-1 to dissociate from the membrane-bound complex. Tumour necrosis factor (TNF) receptor-associated factor-6 ( TRAF-6), a cytoplasmic protein, is activated by ERAK-1 and with TAB-2, another cytoplasmic protein, activates transforming growth factor-P (TFG-P)-activating kinase (TAK-1). During this process both TRAF-6 and TAK-1 become ubiquitinated. TAK-1 then promotes activation of the IkB kinases, or the IKK family, EKKa and EKK 3 (found in a complex with NFicB-essential modulator [NEMO]), which phosphorylate the IkB family, notably IkB-u. IkB-u is an inhibitor of NFkB as it sequesters NFkB in an... 

Szczepanik M, Bryniarski K, Tutaj M, Ptak M, Skrzeczynska J, Askenase PW, Ptak W Epicutaneous immunization induces T-cell receptor CD4 CDS double-positive non-specific suppressor T cells that inhibit contact sensitivity via transforming growth factor-p. Immunology 2005 115 42-54. 

Bertone S, Schiavetti F, Bellomo R, Vitale C, Ponte M, Moretta L, Mingari MC Transforming growth factor-p-induced expression of CD94/NKG2A inhibitory receptors in human T lymphocytes. Eur J Immunol 1999 29 23. 

Transforming growth factor-P, TGF-P1,-P2, -P3 Homodimer of 25 kD TGFP receptor I und II, contains Ser/Thr specific protein kinase activity... 

Receptor Serine/Threonine Receptor Protein Kinase = Receptor Protein Phosphotyrosine Phosphatase = Receptor Tyrosine Kinase = Signal Transducer and Activator of Transcription = Transforming Growth Factor P = Tetradecanoylphorbolacetate = Tetradecanoylphorbolacetate Response Element = Change in Permeability of PM to specific solutes = Change in Transmembrane Potential. 

Beall, M.J. and Pearce, E.J. (2001) Human transforming growth factor-P activates a receptor serine/threonine kinase from the intravascular parasite Schistosoma mansoni. lournal of Biological Chemistry 276, 31613-31619. 

Okadome T, Oeda E, Saitoh M, Ichijo H, Moses HL, Miyazono K, Kawabata M. Characterization of the interaction of FKBP12 with the transforming growth factor-P type I receptor in vivo. Journal of Biological Chemistry 1996, 271, 21687-21690. 

W6. Wikstrom, P., Bergh, A., and Damber, J. E., Expression of transforming growth factor-beta receptor type I and type II in rat ventral prostate and Dunning R3327 PAP adenocarcinoma in response to castration and oestrogen treatment. Urol. Res. 25, 103-111 (1997). 

Fig. 6.5 Signalling through SMAD proteins. Receptor complexes, formed with transforming growth factor.p (TGF-p) and related factors, activins, and bone morphogenetic proteins (BMPs), consist of two serine/threonine receptor kinases, the type II and type I receptors. Binding of the ligand results In autophosphorylation of type I receptors. The activated type I receptors in turn phosphoryiate and activate R-SMADs SMADs 1,...

D. M. Rose, B. W. Winston, E. D. Chan, D. W. H. Riches, and P. M. Henson, Interferon-y and Transforming Growth Factor-P Modulate the Activation of Mitogen-Activated Protein Kinases and Tumor Necrosis Factor-a Production Induced by Fcg-Receptor Stimulation in Murine Macrophages, Biochemical Biophysical Research Communication, 238 (1997) 256-260. 

These receptors have a cysteine-rich extraceUular domain and a cytoplasmic serine/threonine kinase activity.Transforming growth factor-P (TGF-P) superfamily induces growth arrest in epithelial cells. In addition to the three TGF-P isoforms, this family comprises activins, bone morphogenetic proteins and other secreted factors. 

Loughtin, A. J., Woodrofe, M. N., and Cuzner, M. L., Modulation of the interferon-y (induced major histocompatibility complex class II and Fc receptor expression on isolated microglia by transforming growth factor-P, interleukin-4, noradrenaline, and glucocortoids, Immunology, 79, 125, 1993. 

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