Epidermal growth factor receptors interacting proteins

Cohen, S., Carpenter, G., and King, L., Jr. (1980). Epidermal growth factor-receptor-protein kinase interactions. Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity. J. Biol. Chem. 255, 4834-4842. 

Mineral fibers, particularly asbestos, can activate protein kinase C and increase expression of ornithine decarboxylase, the proto-oncogenes, c-fos, and c-jun (18-20), and the nuclear transcription factor, NF-kB (21). All these events are associated with cell proliferation and, potentially, with neoplastic transformation. Recently, Zanella et al. (22) have shown that asbestos activates the mitosis-associated kinase (MAP) system, apparently through interaction with the epidermal growth factor receptor, probably implying that some of these events are mediated by signal transduction pathways that start on the cell surface, rather than by fiber uptake, although this point needs to be directly examined. 

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