Epidermal growth factors receptor, identification

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Spiliotis, M., Kroner, A. and Brehm, K. (2003) Identification, molecular characterization and expression of the gene encoding the epidermal growth factor receptor orthologue from the fox-tapeworm Echinococcus multilocularis. Gene 323, 57-65. 

Elleman, T. C., Domagala, T., McKern, N. M., Nerrie, M., Lonnqvist, B., Adams, T. E., Lewis, J., Lovrecz, G. O., Hoyne, P. A., and Richards, K. M. et al. (2001). Identification of a determinant of epidermal growth factor receptor ligand-binding specificity using a truncated, high-affinity form of the ectodomain. Biochemistry 40, 8930-8939. 

Shao H, Cheng HY, Cook RG, Tweardy DJ. Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor. Cancer Res, 2003,63 3923-3930. 

Agazie YM, Hayman MJ (2003) Development of an efficient substrate-trapping mutant of Src homology phosphotyrosine phosphatase 2 and identification of the epidermal growth factor receptor, Gabl, and three other proteins as target substrates. J Biol Chem 278 13952-13958... 

Hide, G., Gray, A., Harrison, C. M. and Tait, A. (1989) Identification of an epidermal growth factor receptor homologue in trypanosomes. Mol. Biochem. Parasitol. 36 51-60. 

Sheikh MS, Carrier F, Johnson AC et al. (1997) Identification of an additional p53-responsive site in the human epidermal growth factor receptor gene promotor. Oncogene 15 1095-1101... 

A. Pandey, A. V. Podtelejnikov, B. Blagoev, X. R. Bustelo, M. Mann, and H. F. Lodish, Analysis of receptor signaling pathways by mass spectrometry Identification of Vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors, Proc. Natl. Acad. Sci. USA 97 (2000), 179-184. 

The identification of targets with complete or nearly complete specificity is a key challenge. Herceptin , used in breast cancer treatment, binds the Her-2 receptor for epidermal growth factor (EGF). This receptor is present only in a subset of breast cancer patients, providing the specificity... 

Kawamoto, T., Sato, J. D., Jonathan, A. L., Polikoff,J., Sato, G.H., Mendelsohn, J. (1983). Growth stimulation of A432 cells by epidermal growth factor Identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal anti-bidy. Proc. Nat. Acad Sci., 80, 1337—1341. 

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