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Chemokines receptors

Models also can assist in experimental design and the determination of the limits of experimental systems. For example, it is known that three proteins mediate the interaction of HIV with cells namely, the chemokine receptor CCR5, the cellular protein CD4, and the viral coat protein gpl20. An extremely useful experimental system to study this interaction is one in which radioactive CD4, prebound to soluble gpl20, is allowed to bind to cellular receptor CCR5. This system can be used to screen for... [Pg.44]

Cagnon, L., and Rossi, J. J. (2000). Down regulation of the CCRS beta-chemokine receptor and inhibition of HIV-1 infection by stable VAl-ribozyme chimeric transcripts. Antisen. Nuc. A. Drug Dev. 10 251—261. [Pg.196]

Mellado, M., Rodriguez-Frade, J. M., Vila-Coro, A. J., Fernandez, S., MartindeAna, A., Jones, D. R., Toran, J. L., and Mardnez-Aet, C. (2001). Chemokine receptor homo- or heterodimerization activates distinct signaling pathways. EMBO J. 20 2497-2507. [Pg.197]

Central tendency, 226-227 Chemical genomics, 178 Chemical tools, in target-based drug discovery, 178-179 Chemokine C receptor type 1, 133 Chemokine receptors, 6, 44, 53, 129, 132, 177... [Pg.294]

G-protein-coupled Receptors Dopamine System Adenosine Receptors Chemokine Receptors... [Pg.91]

T-cells, representing the adaptive arm of the immune response, also play a critical role in atherogenesis, and enter lesions in response to the chemokines inducible protein-10 (DP-10), monokine induced by DFN-y (MIG), and DFN-inducible T-cell a-chemoattractant (I-TAC), which bind CXCR3 (a chemokine receptor containing two cysteine residues separated by one amino acid), highly expressed by T lymphocytes in the plaque. The... [Pg.225]

CC, and one CX3C and XC chemokine receptors have been cloned so far [2]. Receptor binding initiates a cascade of intracellular events mediated by the receptor-associated heterotrimeric G-proteins. These G-protein subunits trigger various effector enzymes that lead to the activation not only of chemotaxis but also to a wide range of fimctions in different leukocytes such as an increase in the respiratory burst, degranulation, phagocytosis, and lipid mediator synthesis. [Pg.352]

Chemokines have been shown to be associated with a number of autoinflammatory diseases including multiple sclerosis, rheumatoid arthritis, atherosclerosis, dermatitis, and organ transplant rejection. Evidence, reviewed below, is mounting that chemokines may play a major role in the pathophysiology of these diseases and thus chemokine receptor antagonists could prove to be useful therapeutics in treating these and other proinflammatory diseases. [Pg.352]

Although leukocytes continue to be the major site of expression of chemokine receptors, several studies have recently demonstrated chemokine receptor expression on neurons in the CNS. [Pg.352]

Chemokine Receptors. Figure 1 Biological functions of chemokine receptors as exemplified by the chemokine receptor CXCR4. [Pg.352]

A number of viruses, including those in the Heipes and Pox families, express chemokine-like or chemokine receptor-like molecules that presumably help them to... [Pg.354]

Chemokine Receptors. Table 1 Chemokine receptor antagonists in clinical trial... [Pg.354]

Ribeiro S, Homk R (2005) Chemokine receptor antagonists from the bench to tire clinic. Weinheim, Wiley-VCH, pp 371-402... [Pg.355]


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See also in sourсe #XX -- [ Pg.54 ]




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7-transmembrane domain receptors chemokine system

Allergic lung disease chemokine receptor expression

Atypical chemokine receptors

Basophils chemokine/cytokine receptors

Blockade of Chemokine Receptors As a Strategy for Antiretroviral Therapy

C-chemokine receptor

CC chemokine receptors

CC chemokines receptors

CCR3 (chemokine receptor

CXC chemokine receptors

CXC chemokines receptors

CXC chemokines/receptors in lung antimicrobial host defense

Central Nervous System neuronal chemokine receptor expression

Central nervous system chemokine receptor expression

Chemoattractant receptor Chemokines

Chemokine CCR5 receptor

Chemokine Receptor Inhibitor

Chemokine Receptors In Vivo

Chemokine Receptors and Acute Lung Allograft Rejection

Chemokine Receptors and Atherosclerosis

Chemokine Receptors as Drug Targets. Edited by Martine J. Smit, Sergio A. Lira, and Rob Leurs

Chemokine Receptors in COPD

Chemokine Receptors in Cancer Progression

Chemokine Receptors in Inflammatory Bowel Disease

Chemokine Receptors in the Pathogenesis of Lung Allograft Rejection

Chemokine and their Receptors in Atherosclerosis

Chemokine cognate receptors

Chemokine receptor CX3CRI

Chemokine receptor CXCR

Chemokine receptor activation

Chemokine receptor activation, molecular

Chemokine receptor antagonists

Chemokine receptor antagonists, treatment

Chemokine receptor antagonists/inhibitors

Chemokine receptor cross-linking

Chemokine receptor dimerization fluorescence resonance energy transfer

Chemokine receptor expression

Chemokine receptor in multiple sclerosis

Chemokine receptor inhibition

Chemokine receptor knockout

Chemokine receptor modulator

Chemokine receptor modulators

Chemokine receptor oligomerization

Chemokine receptor signaling method

Chemokine receptor therapeutics

Chemokine receptors

Chemokine receptors GPCR family

Chemokine receptors antibodies

Chemokine receptors applications

Chemokine receptors biology

Chemokine receptors blocking

Chemokine receptors cell-surface expression

Chemokine receptors classes

Chemokine receptors couple differentially

Chemokine receptors dendritic cell

Chemokine receptors description

Chemokine receptors drugs modulating

Chemokine receptors immune surveillance

Chemokine receptors inflammation with

Chemokine receptors interactions with

Chemokine receptors intracellular signaling

Chemokine receptors levels

Chemokine receptors ligand structure

Chemokine receptors model

Chemokine receptors neuron detection

Chemokine receptors overview

Chemokine receptors pertussis-toxin sensitive

Chemokine receptors polymorphism

Chemokine receptors processes

Chemokine receptors promiscuous binding

Chemokine receptors redundancy

Chemokine receptors seven-transmembrane

Chemokine receptors signaling

Chemokine receptors viral chemokines

Chemokine-mediated migration receptors

Chemokines and chemokine receptors

Chemokines and chemokine receptors expression

Chemokines and chemokine receptors in)

Chemokines and their Receptors in Central Nervous System Disease

Chemokines and their Receptors in Multiple Sclerosis

Chemokines and their Receptors in Psoriasis

Chemokines receptor dimerization

Chemokines receptor expression

Chemokines receptor family

Chemokines receptor-ligand interactions

Chimeric chemokine receptor

Constitutively Active Viral Chemokine Receptors Tools for Immune Subversion and Pathogenesis

Cysteine chemokine receptors

Decoy chemokine receptor

Dimerization chemokine receptor

Dimerization, of chemokine receptors

Drugs chemokine receptor modulated

Duffy antigen receptor for chemokines

Duffy antigen receptor for chemokines DARC)

Eosinophil chemokine receptors

Eosinophils chemokine/cytokine receptors

Expression of Chemokines and their Receptors in the CNS

Extracellular domain, of chemokine receptors

Extracellular loop chemokine receptors

Fibrosis chemokine receptors

G protein-coupled receptor , chemokine

Genetic Evidence for the Importance of Chemokines and Their Receptors in HIV-1 Pathogenesis

HIV Induces Signals via Chemokine Receptors

Herpesvirus Encoded Chemokines and Chemokine Receptors

Herpesviruses Encode Constitutively Active Viral Chemokine Receptors

Herpesviruses chemokine receptors

Heterodimerization, chemokine receptor

Human immunodeficiency virus chemokine receptors

Inflammation chemokines/chemokine receptors

Intestinal epithelial cell chemokine receptor expressed

Mimicry of Chemokines and Chemokine Receptors by Poxviruses

Molecular pharmacology chemokine receptors

N-terminal chemokine receptor peptides

Neutrophils chemokine/cytokine receptors

Nomenclature System for Chemokine Ligands and Receptors

ORF74 chemokine receptor

Opioid-chemokine receptor interaction

Opioid-chemokine receptor interaction desensitization

Opioid-chemokine receptor interaction function

Opioid-chemokine receptor interaction receptors

Orphan chemokine receptor

Other Chemokines and their Receptors

Poxviruses chemokine receptors

Receptor Heterodimerization with Chemokine Receptors

Receptor bias chemokine system

Receptor-binding epitopes, chemokines

Signal transduction, chemokine receptor

Small-molecule chemokine receptor

Small-molecule chemokine receptor antagonist

Structural Determinants of Ligand Binding and Receptor Activation by CC Chemokines

Structural Insights for Homology Modeling of Chemokine Receptors

Subject chemokine receptor

Targeting Chemokine Receptor Dimers Are there Two (or More) to Tango

The Atypical Chemokine Receptors

The Binding of Chemokines to Chemokine Receptors

The Chemokine Supergene Families of Ligands and Receptors

UL33 chemokine receptor

Versus Induced Chemokine Receptor Dimerization

Viral chemokine receptor

Viruses chemokine receptors

Viruses encoding chemokine receptors

Which Are the Important Chemokine Receptors Used by HIV in Vivo

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