Chemokines receptor dimerization

Hemanz-Falcon P, Rodriguez-Frade JM, Serrano A, et al. Identification of amino acid residues crucial for chemokine receptor dimerization. Nat Immunol 2004 5(2) 216-223. 

Milligan G, Wilson S, Lopez-Gimenez JF. The specificity and molecular basis of alphal-adrenoceptor and CXCR chemokine receptor dimerization. J Mol Neurosci 2005 26 161-168. 

Rodriguez-Frade, J. M Mellado, M., and Martinez-A, C. (2001) Chemokine receptor dimerization two are better than one. Trends Immunol. 22,612-617. 

Fig. 7. Structural model of CCR5 dimer association presented as a ribbon representation. TMl, TM2, and TM4 (labeled al, a2 and o4) participate directly in the interaction surface. The positions of the mutated residues, V150 and 152, are indicated on each of the subunits. Reprinted from Nature Immunology, with copyright permission from the Nature Publishing Group Hernanz, P., etal. (2004). Identification of amino acid residues crucial for chemokine receptor dimerization. Nature Immunology 5,216-22 i. (See Color Insert.)...

Before attempting analysis of chemokine receptor dimerization, the cell system should be characterized in detail Note 1). This includes routine testing such as analysis of cell cycle status, cell surface receptor expression and determination of receptor number and affinity constants, especially when cells are transfected with mutant or fluorescently labeled receptors. 

Targeting Chemokine Receptor Dimers Are there Two (or More) to Tango ... 

Constitutive Versus Induced Chemokine Receptor Dimerization 93... 

Patho-) Physiological Consequences cf Chemokine Receptor Dimerization 95... 

Patho-)Physiological Consequences of Chemokine Receptor Dimerization 97... 

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