Atypical chemokine receptors

Nibbs, R. J., D. S. Gilchrist, V. King, A. Ferra, S. Forrow, K. D. Hunter and G. J. Graham (2007). The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors. J Clin Invest 117(7) 1884-1892. 

Bachelerie, F., Ben-Baruch, A., Burkhardt, A. M., Combadiere, C., Farber, J. M., Graham, G. J., et al. (2014). International Union of Pharmacology. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacological Reviews, 66, 1-79. 

HanseU, C. A., Schiering, C., Kinstrie, R., Ford, L., Bordon, Y., Mclnnes, I. B., etal. (2011). Universal expression and dual function of the atypical chemokine receptor D6 on innate-hke B cells in mice. Blood, 117, 5413—5424. 

Ulvmar, M. H., Werth, K., Braun, A., Kelay, P., Hub, E., Eller, K., etal. (2014). The atypical chemokine receptor CCRLl shapes functional CCL21 gradients in lymph nodes. Nature... 

Odemis, V., Lipfert, J., Kraft, R., Hajek, P., Abraham, G., Hattermann, K., et al. (2012). The presumed atypical chemokine receptor CXCR7 signals through G(i/o) proteins in primary rodent astrocytes and human glioma cells. Glia, 60(3), 372-381. 

Finally, the atypical chemokine receptors ACKRl—6 (Bachelerie et al., 2014) are able to recruit chemokines and signal via P-arrestin-dependent pathways, but do not couple to G proteins (Graham, Locati, Mantovani, Rot, Thelen, 2012). Thus, scavenger or atypical receptors are firUy biased toward G protein-independent pathways. 

Here, we give detailed instructions for each step involved in production of complexes between chemokine receptors and chemokines through coexpression in Sf9 cells for structural and biophysical studies without the need for small-molecule Hgands or separately purified chemokines. Using the production of a complex between atypical chemokine receptor 3,... 

Nibbs, R. J., Graham, G. J. (2013). Itnmime regulation by atypical chemokine receptors. Nature Reviews Immunology, 15(11), 815—829. 

Borroni, E. M., CanceDieri, C., Vacchini, A., Benureau, Y., Lagane, B., Bachelerie, F., et al. (2013). p-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6. Science Signaling, 6(273), ra30 31-11, S31-33. 

Table 4.1 The chemokine-binding profiles of the atypical chemokine receptors.

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