Genomics chemical

Central tendency, 226-227 Chemical genomics, 178 Chemical tools, in target-based drug discovery, 178-179 Chemokine C receptor type 1, 133 Chemokine receptors, 6, 44, 53, 129, 132, 177... 

Pittsburgh Molecular Libraries Screening Center, University of Pittsburgh, Pittsburgh, PA 15260 and Penn Center for Molecular Discovery, University of Pennsylvania, Philadelphia, PA 19104, USA San Diego Center for Chemical Genomics, Burnham Institute for Medical Research, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA... 

Jung M, Kim H, Kim M (2003) Chemical genomics strategy for the discovery of new anticancer agents. Curr Med Chem 10(9) 757-762... 

Luc Brunsveid, Max Planck Institute of Molecular Physiology and Chemical Genomics Centre of the Max Planck Society, Dortmund, Germany... 

Falb, D., Jindal, S. Chemical genomics bridging the gap between the proteome and therapeutics. Curr. Opin. Drug Discovery Dev. 2002, 5, 532-539. 

The PSSC concept may open up new opportimities for research in the developing field of chemical genomics. Central to this field is the identification of small molecule lead-like compounds that bind to a gene family product (i.e. a protein). Such small molecules can subsequently be used to elucidate the function of other gene products/proteins of the same gene family. The PSSC concept may broaden this approach by considering more distantly related genes and proteins. 

The NIH set up a Chemical Genomics Center (NCGC) in 2007 to reproduce the facilities found in the best of the pharmaceutical company screening programs. NCGC runs a variety of tests at 15 dilutions from a highest concentration of about 92 J,M and, in the examples above, this would detect the genotoxicity of the most potent compounds, but not the least potent - and most likely irrelevant positive results. 

Chemical genomics profiling of environmental chemical modulation of hmnan nuclear receptors. Environ Health Perspect 119 1142-1148... 

The resultant master ORF clones should be checked by several different criteria DNA sequence, protein productivity, and the structure of produced proteins see Note 5). Once these master ORF clones whose quality has been well-checked become available to the research community, a wealth of time, labor, and cost will surely be saved and provide a solid basis for reverse chemical genomic approaches. In this context, many groups working on ORFeome cloning have made their ORF clones open to the research community For human ORF clones, the ORFeome collaboration is actively working to generate a complete set of human ORF clones as an international collaboration (http // www.orfeomecollaboration.org/) Schizosaccharomyces pombe ORF clones are already available at the DNA bank of RIKEN... 

Computational Overview of GPCR Gene Universe to Support Reverse Chemical Genomics Study... 

Key words Reverse chemical genomics, G-protein coupled receptor, Eukaryote genome, Gene... 

Application of SEVENS and GRIFFIN to Reverse Chemical Genomics... 

Figure 4 shows the flow of GPCR gene analysis for the purpose of supporting the reverse chemical genomics approach. 

Fig. 4. Work flow of GPCR gene classification and in-silico functional prediction using SEVENS and GRIFFIN, to support reverse chemical genomics.

The main objective in gene module analysis of reverse chemical genomics is to find new functional relationships between different chemicals. Once a set of gene modules annotated by GO and KEGG is obtained, check the common function names for every combination of query chemicals with a significant p value threshold. 

Spring, D. R., (2005) Chemical genetics to chemical genomics small molecules offer big insights. Chem. Soc. Rep. 34, 472-482. 

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