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Chemokine receptors overview

D Ambrosio, D., Panina-Bordignon, P., and Sinigaglia, F. (2003). Chemokine receptors in inflammation An overview./. Immunol. Methods 273, 3-13. [Pg.383]

Although additional chemokines and chemokine receptors will probably continue to be identified for some time, adding to what is already a system of enormous complexity, there is already enough known to discern important patterns of specificity and activity, as described in this overview. An area which... [Pg.7]

Figure 3 Chemokine receptor signaling pathways. Rough overview of the signaling pathways mediated by chemokine receptors that lead to migration or contribute to cell survival and proliferation. For outcomes highlighted in pink, assays are described in is an artificial G protein used in an iPs turnover assay to mea-... Figure 3 Chemokine receptor signaling pathways. Rough overview of the signaling pathways mediated by chemokine receptors that lead to migration or contribute to cell survival and proliferation. For outcomes highlighted in pink, assays are described in is an artificial G protein used in an iPs turnover assay to mea-...
Chemokines and chemokine receptors An overview. Frontiers in Biosdence (Landmark Ed), 14, 540-551. [Pg.438]

Bonecchi, R., GaHiera, E., Borroni, E. M., Corsi, M. M., Locati, M., Mantovani, A. (2009). Chemokines and chemokine receptors An overview. Frontiers in Bioscience... [Pg.455]

Chemokines are chemotactic cytokines that induce directional sensing and motile responses (defined as chemotaxis) in cells expressing the corresponding chemokine receptors. Chemokines are small (approx. lOkDa), mostly secreted proteins that were initially implicated in the regulation ofblood cell trafficking during host defense and immune responses initiated by pathogens. The first molecule with chemotactic properties (IL-8) was identified in 1987 [1] and since then the chemokine family has expanded rapidly to its current size. The family now consists in humans of 53 chemokines and 23 chemokine receptors (for an overview, seehttp //cytokine.medic. kumamoto-u.ac.jp/CFC/CK/Chemokine.html) [2]. [Pg.151]

A wide variety of ligands that use STM receptors and share signal transduction pathways will be considered and compared in this overview. This includes cell-derived chemokines, ETB4, PAF, complement-derived C5a, bacterial-derived fMFP, neuropeptides, and related ligands. [Pg.2]

Figure 2 Construct design of receptor and chemokine sampies. (A) Schematic overview of chemokine and receptor constructs. (B) SDS-PAGE of purified ACKR3 showing the effect of promoter and tag piacement on the finai yieid of ACKR3 protein. The doubiing and fuzziness of the ACKR3 band is due to giycosyiation. Figure 2 Construct design of receptor and chemokine sampies. (A) Schematic overview of chemokine and receptor constructs. (B) SDS-PAGE of purified ACKR3 showing the effect of promoter and tag piacement on the finai yieid of ACKR3 protein. The doubiing and fuzziness of the ACKR3 band is due to giycosyiation.
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