Viruses encoding chemokine receptors

Rosenkilde, M. M. (2005). Virus-encoded chemokine receptors—Putative novel antiviral drug targets. Neuropharmacology, 48, 1—13. 

Virus-Encoded Chemokine Receptor (SECRET) Domain... 

Jensen, K.K., D.J. Manfra, M.G. Grisotto, A.P. Martin, G. Vassileva, K. Kelley, T.W. Schwartz, and S.A. Lira. The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposi s sarcoma. J Immunol 174 3686-94, 2005. 

Fig. 1. Human cellular and human CMV-encoded chemokine receptors and their corresponding ligands. Cellular chemokine receptors that bind only one ligand (single ligand) or those that bind several ligands (multiple ligands) are shown. The human herpesvirus chemokine receptors (virus encoded) and their ligands are given where determined. The old nomenclature has been used here. For the new nomenclature see Murphy et al. (2000)...

The US28-encoded chemokine receptor can serve as a coreceptor for human immunodeficiency virus (HIV) entry and play a role in cell-to-cell fusion between cells expressing HIV envelopes and those expressing pUS28 (Choe et al. 1998 Ohagen... 

Arnold PL, Fremont DH. Structural determinants of chemokine binding by an ectromelia virus-encoded decoy receptor. J Virol 2006 80(15) 7439-7449. 

Rucker J, Edinger AL, Sharron M et al (1997) Utilization of chemokine receptors, orphan receptors, and herpesvirus-encoded receptors by diverse human and simian immunodefidency viruses. J Virol 71 8999-9007... 

It has been known for some time that herpesviruses encode functional chemokine receptors (11). One of the theories for the existence of such receptors is that they play an important part in allowing the virus to disseminate itself in vivo (see ref. 12 for a review). In late 1996, this picture was complicated further when automated searches for novel chemokines, such as those described above, uncovered two or three new chemokines in herpesvirus 8,... 

Virally encoded chemokines have also been discovered, in several herpesviruses (e.g. HHV-8, mouse cytomegalovirus) and in molluscum conta-giosum virus (MCV), a human poxvirus which causes the skin disease molluscum contagiosum. Interestingly, broad-spectrum chemokine receptor antagonist activity has been reported for several of these molecules, including vMIP-II of HHV-8 and MC148R of... 

Virus-encoded receptors for cytokines and chemokines. Semin. Cell Dev. Biol. 9, 359-368. 

Viruses have developed a wide variety of responses to the host immune system. DNA viruses, such herpes viruses and pox viruses have the ability to encode genes that can manipulate the host immune response. Many of these genes encode for cytokines, cytokine receptors, included chemokines and chemokine receptors (Wells and Schwartz,... 

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