The Atypical Chemokine Receptors

Mark D. Singh, Robert J. B. Nibbs, and Gerard J. Graham 

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Nibbs, R. J., D. S. Gilchrist, V. King, A. Ferra, S. Forrow, K. D. Hunter and G. J. Graham (2007). The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors. J Clin Invest 117(7) 1884-1892. 

HanseU, C. A., Schiering, C., Kinstrie, R., Ford, L., Bordon, Y., Mclnnes, I. B., etal. (2011). Universal expression and dual function of the atypical chemokine receptor D6 on innate-hke B cells in mice. Blood, 117, 5413—5424. 

Ulvmar, M. H., Werth, K., Braun, A., Kelay, P., Hub, E., Eller, K., etal. (2014). The atypical chemokine receptor CCRLl shapes functional CCL21 gradients in lymph nodes. Nature... 

Finally, the atypical chemokine receptors ACKRl—6 (Bachelerie et al., 2014) are able to recruit chemokines and signal via P-arrestin-dependent pathways, but do not couple to G proteins (Graham, Locati, Mantovani, Rot, Thelen, 2012). Thus, scavenger or atypical receptors are firUy biased toward G protein-independent pathways. 

Borroni, E. M., CanceDieri, C., Vacchini, A., Benureau, Y., Lagane, B., Bachelerie, F., et al. (2013). p-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6. Science Signaling, 6(273), ra30 31-11, S31-33. 

Table 4.1 The chemokine-binding profiles of the atypical chemokine receptors.

Graham, G.J. (2009) D6 and the atypical chemokine receptor family novel regulators of immune and inflammatory processes. European Journal of Immunology, 39, 342-351. 

Bordon, Y. et al. (2009) The atypical chemokine receptor D6 contributes to the development of experimental colitis. Journal of Immunology (Baltimore, Md 1950), 182, 5032-5040. 

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