Duffy antigen receptor for chemokines DARC

Patterson AM, Siddall H, Chamberlain G, Gardner L, Middleton J. Expression of the duffy antigen/receptor for chemokines (DARC) by the inflamed synovial endothelium. J Pathol 2002 197(1) 108-116. 

Shen, H., R. Schuster, K. F. Stringer, S. E. Waltz and A. B. Fentsch (2006). The Duffy antigen/receptor for chemokines (DARC) regulates prostate tumor growth. FASEB J 20(1) 59-64. 

Choe, H., Moore, M. J., Owens, C. M., Wright, P. L., Vasilieva, N., Li, W., Singh, A. P., Shakri, R., Chitnis, C. E., and Farzan, M. (2005). Sulphated tyrosines mediate association of chemokines and Plasmodium vivax Duffy binding protein with the Duffy antigen/ receptor for chemokines (DARC). Mol. Microbiol. 55,1413-1422. 

Horuk, R. (2015). The Duffy antigen receptor for chemokines DARC/ACKRl. Frontiers in Immunology, 6, 279. 

Dawson, TC. et al. (2000) Exaggerated response to endotoxin in mice lacking the Duffy antigen/receptor for chemokines (DARC). Blood, 96, 1681-1684. 

There are two major classes of chemokine receptors. The CC receptors bind to the CC chemokines and are named CCRl to 9 the CXC chemokines selectively bind to the CXC receptors, termed CXCRl to CXCR5. This group also comprises receptors for fractalkine (CX3CRI) and lymphotactin (XCRl), as well as the Duffy antigen receptor for chemokines (DARC), which has been shown to bind promiscuously to both CXC and CC chemokines. Finally, there is a receptor termed D6, which has been renamed CCRIO by some investigators. 

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