Fibrosis chemokine receptors

Abbadie C, Lindia JA, Cumiskey AM, Peterson LB, Mudgett JS, Bayne EK, DeMartino JA, MacIntyre DE, Forrest MJ (2003) Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2. Proc Natl Acad Sci USA 100 7947-7952 Agostini C, Gurrieri C (2006) Chemokine/cytokine cocktail in idiopathic pulmonary fibrosis. Proc Am Thorac Soc 3 357-363... 

Anders HJ, Vielhauer V, Frink M, et al. A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. J Clin Invest 2002 109 251-259. 

Key Words Fibrosis chemokines chemokine receptors inflammation wound healing Thl Th2. 

Chemokines and Chemokine Receptors in Animal Models of Pulmonary Fibrosis... 

Murine models have been instrumental in representing human disease in vivo. Transgenic approaches have produced mice with genetic defects that promote susceptibility to fibrosis, including abnormal expression of chemokines and/or chemokine receptors. These models have elucidated the factors that are conducive to fibrosis and have thus revealed the central roles of certain chemokines and chemokine receptors. Conventional methods of inducing... 

Fibrosis is a dynamic progression of dysregulated wound healing that results from chronic inflammation. It is a common pathology regardless of the tissue involved, and therefore, the mechanisms that progress to fibrosis can be widely applied. The recruitment, activation, and proliferation of inflammatory cells and their cooperation with resident cells appears to rely on the action of chemokines and the differential expression of the chemokine receptors by these cells. Thus, chemokine receptors make particularly attractive therapeutic targets. 

Huaux F, Gharaee-Kermani M, Liu T, et al. Role of eotaxin-1 (CCL11) and CC chemokine receptor 3 (CCR3) in bleomycin-induced lung injury and fibrosis. Am J Pathol 2005 167(6) 1485-1496. 

Johnston CJ, Williams JP, Okunieff P, Finkelstein JN. Radiation-induced pulmonary fibrosis examination of chemokine and chemokine receptor families. Radiat Res 2002 157(3) 256-265. 

Okuma T, Terasaki Y, Kaikita K, et al. C-C chemokine receptor 2 (CCR2) deficiency improves bleomycin-induced pulmonary fibrosis by attenuation of both macrophage infiltration and production of macrophage-derived matrix metallo-proteinases. J Pathol 2004 204(5) 594-604. 

Pignatti P, Brunetti G, Moretto D, et al. Role of the chemokine receptors CXCR3 and CCR4 in human pulmonary fibrosis. Am J Respir Crit Care Med 2006 173(3) 310—317. 

Key Words Chemokine chemokine receptor angiogenesis inflammation fibrosis cancer. 

Treatment with antibodies to CCRl led to a reduction in both inflammatory cell inflltrates and the development of flbrosis (80). Similar effects have been seen in murine model of obliterative bronchiolitis where the flbrotic response associated with this disorder was attenuated in CCR2 mice (65). This suggests that targeting chemokine receptors may be an efficient way to inhibit pulmonary fibrosis. 

Russo, R. C., Guabiraba, R., Garcia, C. C., Barcelos, L. S., Roffe, E., Souza, A. L., et al. (2009). Role of the chemokine receptor CXCR2 in bleomycin-induced pulmonary inflammation and fibrosis. American Journal of Respiratory Cell and Molecular Biology, 40(4), 410 21. 

Anders, H., Vielhauer, V., Frink, M., Linde, Y., Cohen, C., Blattner, S., Kretzler, M., Strutz, F., Mack, M., Grone, H., Onuffer, J., Horuk, R., Nelson, P., and Schlondorff, D. (2002). A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. J. Clin. Invest. 109, 251-259. 

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