Viral chemokine receptors

Chemokines are small chemotactic cytokines that act as important messenger molecules between cells of the immune system. Chemokines produce their effects by activating a family of G-protein-coupled receptors. Chemokine receptors are all seven-transmembrane glycoproteins that are structurally related. They may be characterized into those that bind to specific ligands, or those that bind several chemokine ligands. There are also virally encoded (viral) chemokine receptors that represent shared receptors that have been transduced into the viral genome during evolutionary history (Premack and SchaU 1996). 

Viral Chemokine Receptor Activities and Receptor-L and Selectivity... 

Beisser PS. Viral chemokine receptors and chemokines in human cytomegalovirus trafficking and interaction with the immune system. CMV chemokine receptors. Curr Top Microbiol Immunol... 

The use of viral chemokine/receptor mimics and inhibitors identified in particular virus families such as herpesviruses, poxviruses and HIV indicates their importance in pathogensis of these viruses, either for evasion of the immune response as with poxviruses and herpesviruses or addtionally the use of recptors for viral entry as with HIV and poxviruses. Further studies will almost certainly identify a greater range of viruses producing such mimics. 

Viral Chemokine Receptors and Chemokines in Human Cytomegalovirus Trafficking and Interaction with the Immune System... 

Murphy, P. M. (2015). Viral chemokine receptors. Frontiers in Immunology, 6, 281. 

Liu, C., Sandford, G., Fei, G., Nicholas, J. (2004). Galpha protein selectivity determinant specified by a viral chemokine receptor-conserved region in the C tail of the human herpesvirus 8 g protein-coupled receptor. Journal of Virology, 78 S), 2460-2471. 

Constitutively Active Viral Chemokine Receptors Tools for Immune Subversion and Pathogenesis... 

Herpesviruses Encode Constitutively Achve Viral Chemokine Receptors... 

Herpesviruses Encode ConstHutively Active Viral Chemokine Receptors 191... 

Table 9.3 Signaling abilities of viral chemokine receptors and determined functions in pathological settings. S ... 

Herpesvirus class Viral chemokine receptor P-HHV US28 P-HHV UL33 U51 y-HHV ORF74 Biin c JJ. < > a... 

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