Chemokine receptors polymorphism

Abdi R, Tran TB, Sahagun-Ruiz A, et al. Chemokine receptor polymorphism and risk of acute rejection in human renal transplantation. J Am Soc Nephrol 2002 13 754-758. 

Strieter RM, Belperio JA. Chemokine receptor polymorphism in transplantation immunology no longer just important in AIDS. Lancet 2001 357 1725-1726. 

It may be possible to derive somewhat analogous information from observations of the phenotype of naturally occurring chemokine receptor polymorphisms in the context of HIV infection, both in vivo and in vitro. These kinds of investigation of the interaction between HIV and its coreceptors potentially contribute not only to an improved understanding of HIV pathogenesis, but also to the rational design of vaccine and drug interventions in clinical infection. 

Chemokine receptor polymorphisms and human immunodeficiency virus disease progression. J. Infect. Dis. 180, 1096-1105. 

Rathore A, Chatterjee A, Sivarama P, Yamamoto N, Singhal PK, Dhole TN (2008) Association of RANTES -403 G/A, -28 C/G and Inl.l T/C polymorphism with HlV-1 transmission and progression among North Indians. J Med Virol 80 1133-1141 Ribeiro S, Horuk R (2005) The clinical potential of chemokine receptor antagonists. Pharmacol... 

Zapico I, Coto E, Rodriguez A, Alvarez C, Torre JC, Alvarez V. CCR5 (chemokine receptor-5) DNA-polymorphism influences the severity of rheumatoid arthritis. Genes Immun 2000 l(4) 288-289. 

Pokomy V, McQueen F, Yeoman S, et al. Evidence for negative association of the chemokine receptor CCR5 d32 polymorphism with rheumatoid arthritis. Ann Rheum Dis 2005 64(3) 487 190. 

The basic biology of chemokines and their receptors is well covered in Chapters 2 and 3 of this book, and we will focus hereafter upon the roles of individual chemokines and receptors in atherosclerosis. The largest amount of data on the roles of chemokines in cardiovascular disease (C VD) has been obtained from in vitro studies and murine models, which will be discussed in detail. In man, genetic polymorphisms in chemokine and chemokine-receptor genes have pointed to an important role for specific chemokines in various atherosclerotic diseases including coronary artery disease and carotid artery occlusive disease. For properties see Table 1. 

Hizawa N, Yamaguchi E, Furuya K, Jinushi E, Ito A, Kawakami Y. The role of the C-C chemokine receptor 2 gene polymorphism V64I (CCR2-64I) in sarcoidosis in a Japanese population. Am J Respir Crit Care Med 1999 159(6) 2021-2023. 

Valdes AM, Wolfe ML, O Brien EJ, et al. Val64Ile polymorphism in the C-C chemokine receptor 2 is associated with reduced coronary artery calcification. Arterioscler Thromb Vase Biol 2002 22(11) 1924-1928. 

McDermott DH, Halcox JP, Schenke WH, et al. Association between polymorphism in the chemokine receptor CX3CR1 and coronary vascular endothelial dysfunction and atherosclerosis. Circ Res 2001 89(5) 401—407. 

Chemokine receptor (CCR5) polymorphisms and reduced susceptibility to human immunodeficiency virus (HIV) infection... 

Szalai, C., Csaszar, A., Czinner, A., et al. (1999) Chemokine receptor CCR2 and CCR5 polymorphisms in children with insulin-dependent diabetes mellitus. Pediat. Res. 46, 82-84. 

Zimmermann N, Bernstein JA, Rothenberg ME (1998) Polymorphisms in the human CC chemokine receptor-3 gene. Biochim Biophys Acta 1442 170-176... 

Cytokine and chemokine receptors An association between systemic sclerosis and polymorphisms in the CXCR-2 gene has been reported (Renzoni et al., 2000). 

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