Dendritic cells chemokine receptors

Yang D, Howard OMZ, Chen Q, Oppenheim JJ. Cutting edge Immature dendritic cells generated from monocytes in the presence of TGF-betal express functional C-C chemokine receptor 6. J Immunol 1999 163 1737-1741. 

Sozzani S, Allavena P, D Amico G, et al. Differential regulation of chemokine receptors during dendritic cell maturation a model for their trafficking properties. J Immunol 1998 161 1083-1086. 

Chemokine Receptors in Naive Circulating Dendritic Cell Precursors... 

Fig. 2. Chemokine receptors on DC subtypes. mDCpre, myeloid dendritic cell precursor pDCpre, plasmacytoid dendritic cell precursor.

Langenkamp A, Nagata K, Murphy K, Wu L, Lanzavecchia A, Sallusto F. Kinetics and expression patterns of chemokine receptors in human CD4+ T lymphocytes primed by myeloid or plasmacytoid dendritic cells. Eur J Immunol 2003 33 474 182. 

Mantovani A, Allavena P, Vecchi A, Sozzani S. Chemokines and chemokine receptors during activation and deactivation of monocytes and dendritic cells and in amplification of Thl versus Th2 responses. Int J Clin Lab Res 1998 28 77-82. 

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Sato N, Ahuja SK, Quinones M, et al. CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Thl)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 cytokines, b cell outgrowth, and sustained neutrophilic inflammation. J Exp Med 2000 192(2) 205-218. 

CC Chemokine Receptor 2 (CCR2) is a member of the G protein-coupled receptor (GPCR) superfamily that serves as the receptor for monocyte chemoattractant proteins 1-4 (MCP-1 to -4), a group of pro-inflammatory chemotactic cytokines (chemokines). CCR2 is the primary chemokine receptor on inflammatory monocytes, and is also expressed on T-cells, dendritic cells, and endothelial cells. Upon ligand engagement, CCR2 mediates both cellular movement and activation. 

Robays LJ, Maes T, Lebecque S, Lira SA, Kuziel WA, Brusselle GG, Joos GF, Vermaelen KV Chemokine receptor CCR2 but not CCR5 or CCR6 mediates the increase in pulmonary dendritic cells during allergic airway inflammation. J Immunol 2007 178 5305-5311. 

Fainaru 0, Shseyov D, Hantisteanu S, Groner Y Accelerated chemokine receptor 7-mediated dendritic cell migration in Runx3 knockout mice and the spontaneous development of asthma-like disease. Proc Natl Acad Sci USA 2005 102 10598-10603. 

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