Dimerization, of chemokine receptors

Springael JY, Urizar E, Parmentier M. Dimerization of chemokine receptors and its functional consequences. Cytokine Growth Factor Rev 2005 16(6) 611-623. 

Thelen, M., and Baggiolini, M. (2001). Is dimerization of chemokine receptors functionally relevant Sci. STKE 2001, PE34. 

Springael, J.Y., Urizar, E., and Parmentier, M. (2005) Dimerization of chemokine receptors and its fimctional consequences. Cytokine ej Growth Factor Reviews, 16, 611-623. 

Rodriguez-Frade JM, Vila-Coro AJ, de Ana AM, Albar JP, Martinez AC, Mellado M. The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2. Proc Natl Acad Sci U S A 1999 96 3628-3633. 

The classical view of GPCR signal transduction involves activation of trimeric G-proteins, and in the case of chemokine receptors, Gai is key, as indicated by their sensitivity to pertussis toxin. However, evolving theories of dimerization-induced signal transduction add an intermediate... 

Before attempting analysis of chemokine receptor dimerization, the cell system should be characterized in detail Note 1). This includes routine testing such as analysis of cell cycle status, cell surface receptor expression and determination of receptor number and affinity constants, especially when cells are transfected with mutant or fluorescently labeled receptors. 

Salanga, C. L., O Hayre, M., Handel, T. (2009). Modulation of chemokine receptor activity through dimerization and crosstalk. Cellular and Molecular Life Sciences, 66(8), 1370-1386. 

Tan,J. H., Ludeman, J. P., Wedderbum, J., Canals, M., HaU, P., Buder, S. J., etal. (2013). Tyrosine sulfetion of chemokine receptor CCR2 enhances interactions with both monomeric and dimeric forms of the chemokine monocyte chemoattractant protein-1 (MCP-1). The Journal of Biological Chemistry, 288(14), 10024—10034. 

Patho-) Physiological Consequences of Chemokine Receptor Dimerization... 

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