C-chemokine receptor

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Hogaboam, C.M. et al., Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C-C chemokine receptor 2, Am. J. Pathol., 156, 1245, 2000. 

K. C. Chemokine receptor-ligand interactions measured using time-resolved fluorescence. Biochemistry 1998, 37, 2372-2377. 

Chemokine receptors are a family of G protein-coupled receptors that contain seven transmembrane domains. Chemokine receptors are present on the cell surface membrane of leukocytes. As was the case for chemokines, these receptors are also divided into four subgroups CCR is specific for CC chemokines, CXCR for CXC chemokines, XCR1 for C chemokines and CX3CR1 for CX3C chemokines. The CC chemokine receptor family has eleven members, the CXC chemokine receptor family has seven members, and both the C chemokine receptor family and the CX3C chemokine receptor family have one member each. The signal transduction is mediated via the standard G protein-dependent pathway. 

Initial tests were performed on a pool of 1,000 compounds, including seven known antagonists. Two scoring methods were able to place half the known antagonists into the top 5% of all docked compounds. This exercise validated the model of the C-C chemokine receptor type 5 binding pocket as well as the scoring method for complex evaluation. 

Y6. Ying, S., Meng, Q., Zeibecoglou, K., Robinson, D. S., Macfarlane, A., Humbert, M., and Kay, A. B., Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (intrinsic) asthmatics. J. Immunol. 163,6321—6329 (1999). 

Arai, H., Tsou, C.-F., and Charo, I. F. (1997) Chemotaxis in a lymphocyte cell line transfected with C-C chemokine receptor 2B Evidence that directed migration is mediated by bg dimers released by activation of Gai-coupled receptors. Proc. Natl. Acad. Sci. USA 94, 14,495-14,499. 

Kuang Y, Wu Y, Jiang H, Wu D (1996) Selective G protein couphng by C-C chemokine receptors. J Biol Chem 271 3975-3978. 

Fukunaga S, Maeda K, Noda E, et al. (2006) Association between expression of vascular endothelial growth factor C, chemokine receptor CXCR4 and lymph node metastasis in colorectal cancer. Oncology 71 204-211... 

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