Chimeric chemokine receptor

Cagnon, L., and Rossi, J. J. (2000). Down regulation of the CCRS beta-chemokine receptor and inhibition of HIV-1 infection by stable VAl-ribozyme chimeric transcripts. Antisen. Nuc. A. Drug Dev. 10 251—261. 

Niwa R, Shoji-Hosaka E, Sakurada M, et al. Defucosylated chimeric anti-CC chemokine receptor 4 IgGl with enhanced antibody-dependent cellular cytotoxicity shows potent therapeutic activity to T-cell leukemia and lymphoma. Cancer Res 2004 64 2127-2133. 

CCR4 is a chemokine receptor expressed on H/RSCs in 24% of patients with HL. A chimeric anti-CCR4 antibody KM2760, the Ec region of which is defucosylated to enhance antibody dependent cellular cytotoxicity, is being developed as a novel treatment for patients with CCR4+ HE. 140... 

Ca " flux, 125 Calcium, 211 Carbon-11, 191 Carbopol, 43 Cardiac arrhythmia, 163 Cardiovascular disease, 157 CDD-0102, 135 Cefditoren pivoxil, 59 Chemokine, 305 Chemokine receptors, 287 Chemokines, 287 Chemotaxis, 305 Chimeric, 315 Chloronicotine, 6-, 103 CI-1017, 141... 

CCR3 Receptor Structure. Chimera studies of CCR3 and CCRl receptors show that the N-terminal segments of CCR3 appear to be important for eotaxin binding (77). However, eotaxin remained an effective agonist at this chimeric receptor in either calcium flux or chemotaxis assays. These data are consistent with a multisite model for chemokine-chemo-kine receptor interaction. 

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