Chemokine receptor knockout

Phenotype of Allergic Response in Chemokine Receptor Knockout Mice... 

Boring L, Gosling J, Chensue SW, et al. Impaired monocyte migration and reduced type 1 (Thl) cytokine responses in C-C chemokine receptor 2 knockout mice. J Clin Invest 1997 100(10) 2552-2561. 

Chensue SW, Lukacs NW, Yang TY, et al. Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice. J Exp Med 2001 193(5) 573-584. 

Fainaru 0, Shseyov D, Hantisteanu S, Groner Y Accelerated chemokine receptor 7-mediated dendritic cell migration in Runx3 knockout mice and the spontaneous development of asthma-like disease. Proc Natl Acad Sci USA 2005 102 10598-10603. 

The chemotaxis of mononuclear leukocytes and the migration, growth, and activation of the multiple cell types within atherosclerotic lesions are critical for the chronic inflammatory and fibroproliferative response in atherosclerosis (Ml). Chemokine-mediated attraction of leukocytes to tissues has been shown in atherosclerotic lesions (G8). Studies using knockout and transgenic murine models indicated that chemokine receptor/ligand interactions are crucial in the development of atherosclerosis (P6). Moreover, chemokines may also interfere with smooth muscle cell migration and growth, and platelet activation and other well-defined features of the atherosclerotic process (A2). 

P6. Peters, W., and Charo, I. F., Involvement of chemokine receptor 2 and its ligand, monocyte chemoattractant protein-1, in the development of atherosclerosis Lessons from knockout mice. Curr. Opin. Lipidol. 12, 175—180 (2001). 

Chemokines and chemokine receptors may also play a role in T lymphocyte differentiation into TH1 and TH2 phenotypes, as suggested by studies of CCR1 and CCR2 knockout mice in schistosome egg challenge of the lung however the mechanism underlying this is not yet clear (Boring et al., 1997 Gao et al., 1997). 

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