Chemokine Receptors in COPD

One of the most important chemokines associated in the recruitment of inflammatory cells in COPD is the CXC chemokine CXCL8 ]46]. CXCL8 binds to both CXCRl and CXCR2 chemokine receptors, which are expressed on a broad range of leukocytes, predominantly neutrophils. 

Recent studies demonstrated a significantly increased expression of CXCRl on circulating neutrophils in COPD patients compared to healthy controls [50]. Furthermore, it is established that the expression of CXCR2 in bronchial biopsies of COPD patients is increased [51]. These two receptors have the capacity to regulate the migration of neutrophils into the pulmonary tissue during the neutrophilic inflammation in COPD. Also, activated neutrophils are undoubtedly crucial players in the 

The concentration neutrophils is increased in the sputum and bronchoalveolar lavage fluid (BALF) of COPD patients and this is related to the increased production of CXCLl and CXCL8 [42, 46, 49, 52, 53]. 

CXCRl CXCL6, CXCL7,CXCL8 Neutro, mono/m4  

CXCR2 CXCLl, CXCL2, CXCL3 CXCL5, CXCL6, CXCL7, CXCL8 Neutro, mono/m4  

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