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Receptor bias chemokine system

The term figand bias is used to describe the situation in which the same receptor can activate distinct pathways in response to diflerent ligands (reviewed in Steen et al., 2014 Zweemer et al., 2014). In the chemokine system, figand bias has been identified in relation to different chemokines acting at the same receptor (Rajagopal et al., 2013), chemokine monomers... [Pg.157]

Figure 1 Bias in the chemokine system and other 7TMRs. Biased signaling describes the ability of a receptor to induce different signaling pathways or cellular events. Thereby, different ligands may activate different pathways via the same receptor (ligand bias, A), or the same ligand induces different outcomes at different receptors (receptor bias, B). Also the cell or tissue that "hosts" the ligand receptor interaction can modulate the induced signaling pathway (tissue bias, C). Figure 1 Bias in the chemokine system and other 7TMRs. Biased signaling describes the ability of a receptor to induce different signaling pathways or cellular events. Thereby, different ligands may activate different pathways via the same receptor (ligand bias, A), or the same ligand induces different outcomes at different receptors (receptor bias, B). Also the cell or tissue that "hosts" the ligand receptor interaction can modulate the induced signaling pathway (tissue bias, C).

See other pages where Receptor bias chemokine system is mentioned: [Pg.155]    [Pg.157]    [Pg.160]    [Pg.161]    [Pg.162]    [Pg.400]    [Pg.423]   
See also in sourсe #XX -- [ Pg.160 , Pg.161 ]




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