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Chemokine cognate receptors

Details regarding structural/functional differences among chemokines and their receptors are discussed elsewhere in this volume. Briefly, chemokines (and their cognate receptors) consist of four main classes (CC, CXC, CX3C and C) based on the number and spacing of at least four conserved cysteine residues (Murphy 2002). [Pg.354]

In this chapter, we provide three methods for examining DC-LEC interactions driven by chemokines. The first two allow for phenotypic characterization of DC-LEC interactions, namely static chemotactic migration and adhesion/transmigration under shear flow, as affected by chemokine-receptor interactions or HS targeting. The third allows us to visualize direct interactions between chemokines relevant to the lymphatic microenvironment and their cognate receptors on the surface of trafficking cells (in this case LLC tumor cells). Based on these methods, we were able to... [Pg.350]

The key components of the chemokine system are a group of 8—12 kDa large peptides, known as chemokines, and their cognate 7-transmembrane heHx receptors (7TMRs), also called G protein-coupled receptors (GPCRs). [Pg.156]

See other pages where Chemokine cognate receptors is mentioned: [Pg.15]    [Pg.77]    [Pg.150]    [Pg.153]    [Pg.157]    [Pg.179]    [Pg.183]    [Pg.264]    [Pg.363]    [Pg.296]    [Pg.304]    [Pg.37]    [Pg.2]    [Pg.8]    [Pg.49]    [Pg.63]    [Pg.65]    [Pg.128]    [Pg.75]    [Pg.103]    [Pg.89]    [Pg.90]    [Pg.108]    [Pg.338]    [Pg.351]    [Pg.460]    [Pg.86]    [Pg.246]    [Pg.279]    [Pg.361]    [Pg.362]    [Pg.307]    [Pg.82]    [Pg.1807]    [Pg.37]    [Pg.335]    [Pg.117]    [Pg.1]    [Pg.100]    [Pg.101]    [Pg.80]    [Pg.98]    [Pg.37]    [Pg.112]    [Pg.160]    [Pg.294]    [Pg.309]   
See also in sourсe #XX -- [ Pg.459 ]



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Chemokines receptors

Cognate receptors

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