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Atorvastatin calcium is a white to off-white crystalline powder. [Pg.3]

Atorvastatin is a selective, competitive inhibitor of the 3-hydroxy methyl glutaryl coenzyme A (HMG-CoA) reductase enzyme that is involved in the conversion of HMG-CoA to mevalonate (a precursor of sterols, including cholesterol). A reduction of intracellular cholesterol levels [Pg.3]

Atorvastatin calcium possesses an anti-inflammatory property and reduces the accumulation of inflammatory cells in the atherosclerotic plaques. The drug also inhibits the vascular smooth muscle cell proliferation a key event in the atherogenesis. Atorvastatin also inhibits the platelet function, thereby limiting both the atherosclerosis and the superadded thrombosis and also improves the vascular endothelial function, largely through the amplification of nitric oxide (NO) generation [3-5]. [Pg.4]

A white or slightly yellowish, crystalline powder, odorless and tasteless [5,6]. [Pg.3]


Null (1970) discusses some alternate models for the excess Gibbs energy which appear to be well suited for systems whose activity coefficients show extrema. [Pg.55]

If this criterion is based on the maximum-likelihood principle, it leads to those parameter values that make the experimental observations appear most likely when taken as a whole. The likelihood function is defined as the joint probability of the observed values of the variables for any set of true values of the variables, model parameters, and error variances. The best estimates of the model parameters and of the true values of the measured variables are those which maximize this likelihood function with a normal distribution assumed for the experimental errors. [Pg.98]

An apparent systematic error may be due to an erroneous value of one or both of the pure-component vapor pressures as discussed by several authors (Van Ness et al., 1973 Fabries and Renon, 1975 Abbott and Van Ness, 1977). In some cases, highly inaccurate estimates of binary parameters may occur. Fabries and Renon recommend that when no pure-component vapor-pressure data are given, or if the given values appear to be of doubtful validity, then the unknown vapor pressure should be included as one of the adjustable parameters. If, after making these corrections, the residuals again display a nonrandom pattern, then it is likely that there is systematic error present in the measurements. ... [Pg.107]

COMPONENTS (N.LE.20I MHOSE INDICES APPEAR IN VECTOR 10, GIVEN... [Pg.291]

LILIK CALCULATES TWO RHASE EFFECTIVE LIQUID EQUILIBRIUM RATIOS K FOR ALL N COMPONENTS IN.LE.20) WHOSE INDICES APPEAR IN VECTOR ID,... [Pg.294]

APPEAR IN VECTOR ID, GIVEN TEMPERATURE T, PRESSURE P, AND LIQUID OP... [Pg.296]

WHOSE INDICES APPEAR IN VECTOR ID. FUGACITIES OF HYPOTHETICAL LIQUID... [Pg.309]

This appears to be a complex problem requiring simultaneous solution of the sequence together with heat integration. [Pg.132]

It thus appears that the flow rate of the nonkey components may account for the diflerences between sequences. Essentially, nonkey components have two effects on a separation. They cause... [Pg.145]

In general, the final network design should be achieved in the minimum number of units to keep down the capital cost (although this is not the only consideration to keep down the capital cost). To minimize the number of imits in Eq. (7.1), L should be zero and C should be a maximum. Assuming L to be zero in the final design is a reasonable assumption. However, what should be assumed about C Consider the network in Fig. 7.16, which has two components. For there to be two components, the heat duties for streams A and B must exactly balance the duties for streams E and F. Also, the heat duties for streams C and D must exactly balance the duties for streams G and H. Such balemces are likely to be unusual and not easy to predict. The safest assumption for C thus appears to be that there will be one component only, i.e., C = 1. This leads to an important special case when the network has a single component and is loop-free. In this case, ... [Pg.215]

Adiabatic operation. If adiabatic operation leads to an acceptable temperature rise for exothermic reactors or an acceptable fall for endothermic reactors, then this is the option normally chosen. If this is the case, then the feed stream to the reactor requires heating and the efiluent stream requires cooling. The heat integration characteristics are thus a cold stream (the reactor feed) and a hot stream (the reactor efiluent). The heat of reaction appears as elevated temperature of the efiluent stream in the case of exothermic reaction or reduced temperature in the case of endothermic reaction. [Pg.325]

Note one further point fi om Fig. 16.7. The number of units is 7 in total (including the heater and cooler). Referring back to Example 7.1, the target for the minimum number of units was calculated to be 7. It therefore appears that there was something in our procedure... [Pg.369]

The pinch design method developed earlier followed several rules and guidelines to allow design for minimum utility (or maximum energy recovery) in the minimum number of units. Occasionally, it appears not to be possible to create the appropriate matches because one or other of the design criteria cannot be satisfied. [Pg.372]

It now appears that many hormones (e.g. glucagon and adrenaline) in both animals and plants exert their effects by, as a first step, decreasing or increasing cyclic AMP within the cell. This may possibly occur by modification of the activity of the enzyme AMP cyclase which generates cyclic AMP from ATP. [Pg.121]

Molisch s test A general test for carbohydrates. The carbohydrate is dissolved in water, alcoholic 1-naphthol added, and concentrated sulphuric acid poured down the side of the tube. A deep violet ring is formed at the junction of the liquids. A modification, the rapid furfural test , is used to distinguish between glucose and fructose. A mixture of the sugar, 1-naphthol, and concentrated hydrochloric acid is boiled. With fructose and saccharides containing fructose a violet colour is produced immediately the solution boils. With glucose the appearance of the colour is slower. [Pg.264]

Morphine and its salts are very valuable analgesic drugs but are highly addictive. In addition to suppression of pain, morphine causes constipation, decreases pupillary size and depresses respiration. Only the (-l-)-stereoisoraer is biologically active. They appear to produce their effects on the brain by activating neuronal mechanisms normally activated by... [Pg.266]

They are formed by treatinga-diketones, a-hyd-roxyaldehydes, hydroxyketones, aminoalde-hydes or aminoketones with arylhydrazines. Sugars can be identified by their osazones which have characteristic melting-points, formation times or crystal appearance. [Pg.290]


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AEAPS (Auger electron appearance potential

AOAs appearance

Addition Reactions in Which the Two Ionic Mechanisms Appear to Be Taking Place Simultaneously

Adulteration process appearance

Aesthetic appearance

Aging external appearance

Alkanes general appearance

Aluminium appearance of metal

Aluminum appearance benefits

Analytical signal appearance

And final products Entries in capital letters indicate compounds, reactions, or methods appearing

Aphids appearance

Appearance (physical

Appearance , xxiv

Appearance Energy

Appearance Paraformaldehyde

Appearance Potential X-Ray

Appearance Potentials, Bond Dissociation Energies, and Heats of Formation

Appearance Pure aqueous solutions

Appearance and Colour of Corrosion Products

Appearance and Emulsion Type

Appearance and Foam Type

Appearance and Light Scattering of Liquid Crystals

Appearance and Odor

Appearance and Surface Properties

Appearance and physical properties

Appearance and proliferation

Appearance defects

Appearance diesel fuel

Appearance energy 736 Subject

Appearance energy complications

Appearance energy decomposition

Appearance energy definition

Appearance energy determination

Appearance energy ethyl cation

Appearance energy kinetic shift

Appearance energy thermochemical cycle

Appearance in systemic fluids

Appearance items

Appearance limitations

Appearance mechanism

Appearance of Crystalline Nuclei

Appearance of EC Spectra

Appearance of Histological Eczematous Reactions During Sensitization

Appearance of NMR spectra for system undergoing two-site exchange

Appearance of cells and laboratory cultures

Appearance of plastics

Appearance of the mass spectrum

Appearance of the samples

Appearance potential

Appearance potential charge exchange

Appearance potential correlation scheme

Appearance potential curves

Appearance potential electron impact

Appearance potential energy

Appearance potential isotopic studies

Appearance potential methods, surface analysi

Appearance potential photon impact

Appearance potential spectroscopy fine structure

Appearance potential spectroscopy of lanthanides and their intermetallics

Appearance potential spectroscopy, APS

Appearance potential spectrum

Appearance potential symmetry analysis

Appearance potential, calculating bond

Appearance potential, calculating bond enthalpy from

Appearance potential, molecules

Appearance profile analysis

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Appearance rate

Appearance resolution

Appearance resonance lamp

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Appearance terms Links

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Appearance, Color, Odor, Taste

Appearance, emulsions, factors affecting

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Appear™ optical polymers

Appear™ polymers

Aqueous solutions Appearance

Aromatic compounds appearance

Ascorbic acid addition, appearance

Auger electron appearance potential

Auger electron appearance potential spectroscopy

Auger electron appearance potential spectroscopy, AEAPS

Automotive appearance

Bacteria physical appearance

Bermuda , first appearance

Boron appearance of element

Bulk appearance

Bull’s eye appearance

Caesium appearance of metal

Cake appearance, 342 (Figs

Carbon tetrafluoride, appearance

Casein micelles appearance

Cavitation appearance

Cell appearance

Cerebellar cortex appearance

Cerebrospinal fluid appearance

Changing appearance

Characters appearances and

Chromatographic reactor product appearance

Chromium appearance

Coatings appearance

Cobalt appearance

Colony Appearance (Color)

Color and Appearance

Color appearance

Colour and appearance

Colour appearance

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Colour measurement appearance

Copper appearance

Corrosion features appearance

Crack appearance

Crystal appearance

Del Rios Lost Element Appears in Sweden

Depth of first appearance

Determination of Appearance Energies

Deviations from First Order Appearance

Diffusion flames appearance

Droplet size appearance

Ecotoxic Effects appearing during Degradation in Soil

Effect of controlled-atmosphere storage appearance

Effect on appearance

Electron Appearance Potential Fine

Electron Appearance Potential Fine Structure

Electrospray mass spectrum appearance

Emulsion appearance

Endeavor appearance

Erosion appearance

Extended appearance potential fine

Extended appearance potential fine structur

Extended appearance potential fine structure

External Appearance, Homogeneity, Skew and Waviness

External appearance

Fatigue appearance

Fatigue appearance transgranular

Firebox appearance

First appearance time

Flames appearance

Flow patterns appearance

Food colour appearance measurement in practice

Foods food, appearance

Fracture appearance transition

Fracture appearance transition temperature

Fruit appearance

General Appearance of Inverse 2D Spectra

General Appearance of the Spectrum

Glass appearance

Glucose appearance rates

Golgi cells appearance

Granule cells appearance

Graphs appearance

Group appearance of elements

Group appearance of metals

Harmonics appearance

Heisenberg, Werner appearance

Heroin appearance

How does the spin appear

Hydrogenosomes of Anaerobic Ciliates At Least One Appears to Be a Missing Link

INDEX appearance potential

Impact of bacteria on beer appearance and flavour

Impact of yeast on beer appearance

Intruder states, appearance

Ionization and Appearance Energies

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Labels appearance

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Lighting for appearance assessment

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Liquid products appearance

Liquid water, first appearance

Liquid water, first appearance Earth

Lithium appearance of metal

Maltese Cross appearance

Manganese appearance

Marijuana appearance

Mass spectra appearance potentials

Mass spectrometric appearance potential

Metallic-like appearance

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Output Appearance Options and Issues

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Physical requirements for food appearance assessment

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Plots, changing appearance

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Polymers, formaldehyde Appearance

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Polymorphs appearing first supersaturated solution

Polypropylene copolymers-Appearance

Polypropylene copolymers-Appearance Degradation

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Products Which Appear

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Reference chromatographic method impurities appearing

Reference standards appearance (physical

Resume package appearance

Resumes appearance

Reversible appearance-disappearance

Riboflavin appearance

Rubbed, appearance

Rubidium appearance of metal

Rust Appearance

Rutherford, Ernest appearance

SXAPS (soft x-ray appearance potential

Sample appearance

Scandium appearance

Semicrystalline thermoplastic appearances

Sensory assessment appearance properties

Significance of appearance energies

Smart textiles appearance

Sodium appearance of metal

Soft X-ray appearance potential

Soft X-ray appearence potential spectroscopy

Soft X-ray appearence potential spectroscopy SXAPS)

Soft appearance potential spectroscopy

Soft x-ray appearance potential spectroscopy

Soft x-ray appearance potential spectroscopy SXAPS

Solutions, formaldehyde Appearance

Specific Properties Appearance - Black and White Pigmentation

Spectral Appearance

Spectrometry and Appearance Potentials

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Spotty appearance

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Stability program appearance testing

Steroid Rearrangements Appearances Can Be Deceptive

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Subject appear

Substances that appear to be less active when ionized

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The Millisecond Life of Individual Micelles and their Featureless Appearance

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Tungstic Acid Appears

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Water, first appearance on Earth

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Weevils appearance

What Causes the Pearlescent Appearance of Some Paints

White normal appearing

Whorled appearance

Why a Net Bond exists when it appears to be Nonexistent The Electronic Structures of F2 and Inert Gas Fluorides

Yarn appearance

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