Niacinamide appearance

A yellow complex of 1 molecule of niacinamide with 1 molecule of ascorbic acid also forms readily in solution by what appears to be a charge-transfer reaction. The complex has been prepared in solid form. It has been claimed that the preforming of this complex presents diflBculties with thickening and hardening of mixtures employed in soft gelatin capsules. Guttman and Brooke (289) found the extent of association between niacinamide and ascorbic acid to be pH dependent with maximum adsorbance at pH 3.8. 

Niacinamide has been reported to improve the appearance and elasticity of aging skin [71], Tested in a 4% cosmetic formulation, it showed efficacy relative to placebo in reducing periorbital wrinkles [72],... 

Bissett DL, Oblong JE, Berge CA (2005) Niacinamide a B vitamin that improves aging facial skin appearance. Dermatol Surg 31(7) 860-865... 

The vitamin B complex contains a number of factors which are closely associated in their distribution in nature and have related functions in intermediate metabolism. Of the eleven factors which are available in pure form, five have been shown to be constituents of coenzymes, namely, thiamine, riboflavin, niacinamide, pyridoxine, and pantothenic acid. It seems likely that other B vitamins may be found to function in a similar manner. Two members of the B complex, choline and inositol, appear to have lipotropic activity, and two others, folic acid and vitamin B12, have antianemic properties. Deficiency of vitamins of the B complex is one of the most frequently encountered syndromes of malnutrition in man. 

Pyridine nucleotides are intimately associated with niacin, another B vitamin (the pellagra-preventive factor). Niacin is a simple pyridine derivative, pyridine-3-carboxylic acid or nicotinic acid. The amide (niacinamide, nicotinamide) also prevents pellagra. The vitamin appears in the coenzyme in this form ... 

Another aspect of the transmethylation hypothesis involves the administration of methyl donors (L-methionine) or methyl acceptors (niacin, niacinamide) to schizophrenic patients in order to exacerbate or alleviate, respectively, the psychotic state. Although L-methionine appeared to intensify some schizophrenic symptoms (see Kety), it did not increase the urinary levels of N- or 0-methylated amines. Moreover, the beneficial results reported by Hoffer et al on the use of methyl acceptors in schizophrenia have not been confirmed by other investigators. ... 

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