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Trace plasma appearance

Kinetic data on the cannablnolds are limited, but it appears that they are eliminated slowly from the body. Reported THC half-lives in human plasma have ranged from 19 to 57 h. Because of their high lipid solubility, cannablnolds and their metabolites can be sequestered in fatty tissues, and traces may be detectable for over a week. The pharmacologic significance of these persistent cannablnolds and their metabolites is unknown.26... [Pg.84]

Bone et al.20 originally showed that MP was as highly variable in the infant retina as it is in the adult retina. Z is the dominant carotenoid in the center of the adult retina and L predominates in the periphery (thus, in vivo measures of MP account mostly for zeaxanthin concentration). This ratio appears to be reversed in the infant retina, where L dominates in the center (at this point, of course, the macula is quite immature and similar to the periphery). Although all of the factors responsible for the wide variation in infant MP have not been studied, dietary intake of L and Z is still clearly necessary. Whereas MP can be manipulated in the adult via intake of xanthophyll-rich foods, the obvious concern with infants is that food options are limited to breast milk or manufactured infant formulas. Breast milk contains at least 300 defined nutrients, whereas most infant formulas contain approximately 60-70 defined nutrients76 Currently, infant formula does not contain L and Z in other than trace amounts,76 and many formulas are completely devoid of L. In contrast, breast milk contains L and Z in concentrations that are approximately proportional to maternal intake of these carotenoids.77 These observations are important since many infants are exclusively formula fed. Johnson et al.21 showed that breast-fed infants and formula-fed infants had the same levels of plasma L and Z at birth. After 1 month, however, plasma L and Z significantly increased for the breast-fed infants and decreased in the formula-fed infants. This implies that retinal levels in formula-fed infants are also low. [Pg.98]

Si-H stretching mode. This Si-H band, however, did not appear in the absence of the minute traces of metals. The reaction was controlled by diffusion whose rate was independent of the nature of the metal. The extent of such diffusion, however, was strongly related to the nature of the metal. Van Meerbeck et al. inferred that this Si-H surface species is the same as the species described by Morterra and Low with their reactive silica (27). Tiller et al. (52) also obtained stable surface Si-H bonds by exposing silica pellets to a H2 plasma, provided the silica sample was dehydrated before exposure. [Pg.13]

In a series of manganese tolerance tests, three dietary components —cellulose, pectin, and phytate—were found to reduce plasma uptake of manganese. Although the amount of manganese administered (40-50 mg) in these tolerance tests was much larger than that typically consumed (0.9 to 7.0 mg per day) (55,56), the results were similar to those obtained in bioavailability studies with other trace elements. Thus it appears that diets high In fiber and phytates also reduce the bloavailabllity of manganese. [Pg.119]

When a small-bore column, such as 0.5 mm i.d., was used, aU peaks appeared simultaneously if the volume of the retained stationary phase was over 15%. However, if the retention volume of the stationary phase was less than 10% in a small-bore column, peak separation was observed as shown in Fig. 5. " Each peak was detected by plasma atomic emission spectrometry. This peak profile shows enrichment profiles with separation of Mg, Cu, Mn, and Ca in tap water. The intensity of Ca is shown in the right axis, 3 orders higher than that of the other elements, while the intensity of Mn is amplified 10 times. The spectral interference of Ca to the signal of Cu is observed. This separation phenomenon is considered to be quite useful for exact determination of trace metals. [Pg.850]

Ethchlorvynol. Ethchlorvynol is r -idly absorbed from the gastrointestinal tract and is extensively metabolized mainly in the liver and to a lesser extent in the kidney. The half-life of ethchlorvynol is biphasic with a rapid initial phase and a 10- to 25-h-long terminal phase. Only traces of unchanged drug appear in the urine. The metabolic half-life is 5.6 h, and it disappears from the plasma with a rapid a phase and a much slower j8 phase, because of extensive tissue redistribution. [Pg.221]

Like plasma PSG, the LTO/LPO also contain phosphorus pentoxlde, trioxide, and phosphine. The 4.38 IC peak was not found in most of these films however, when it was found, it appeared as a very slight trace. [Pg.330]

Barba and his colleagues sampled the three outcrops of limestone to determine their distinctive signatures. This information was compared to lumps of calcium carbonate found in the finished plaster in the city. The group of scientists used several different techniques to examine the samples. The major element composition of the geological samples was determined by XRF. The major element composition of the lumps was determined by SEM-EDS. Trace element composition was determined by LA-ICP-MS (laser ablation inductively coupled plasma mass spectrometry) to measure the elemental composition of the plaster and the limestone. This methodology is well suited for analyses of very small lumps with microscopic spot sizes. The LA-ICP-MS method is able to analyze a large number of trace and rare earth elements with speed, precision, and high resolution, especially in cases where the major chemical composition does not appear to be particularly distinctive. The instrument worked extremely well for the characterization and determination of the provenance of the Ume plaster source material. [Pg.67]

In order to find out which acids are actually responsible for the increase of the total organic acids in the blood plasma of uremic patients, Nordmaim et al. (N16) made a chromatographic study on blood plasma samples from 24 patients with acute renal failure. They found that some of the acids, which are present only in trace amounts on chromatograms of normal blood plasma, are greatly increased, while many others, which are absent from normal chromatograms, appear in the plasma during acute renal failure (Fig. 15). [Pg.98]


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