Tablets appearance

Tablets Appearance (cracking, chipping, and mottling), friability, hardness, color, odor, moisture content, clumping, disintegration, and dissolution... 

The tablet was introduced by Thomas Brockedon in 1843, and glyceryl trinitrate tablets appeared in the British Pharmacopoeia of 1885. Since that time, many variations have appeared but the basic process remains unchanged. There are three main methods of tablet manufacture, with choice depending on the dose and the drug s physical properties such as compressibility and flow (Figure 2.2). A drug with a large... 

Tablets - Mesalamine tablets are coated with an acrylic-based resin that delays release of mesalamine until it reaches the terminal ileum and beyond. Approximately 28% is absorbed after oral ingestion, leaving the remainder available for topical action and excretion in the feces. Mesalamine from oral mesalamine tablets appears to be more extensively absorbed than that released from sulfasalazine. 

The intake in infants and young children from fluoridated salt containing 250 mg/kg of fluoride is, in infants and young children, so low in Germany that additional fluoride tablets appear to be justified. 

The bioavailability of the buprenorphine/naloxone tablet appears to be greater than the buprenor-phine-alone formulation, with the former similar to the drug in liquid form. Buprenorphine is approximately 96% plasma protein bound, primarily to a- and [3-globulin. The plasma half-life is... 

Lead curse tablets from Roman Carthage contain variable amounts of very small metallic inclusions. Electron microprobe analysis confirmed these metallic inclusions were bronze, brass, and a Sn-Sb alloy. This was interpreted as possible evidence of lead metal recycling. Six samples were chosen to represent a range of tablets containing the minimum to the maximum number of inclusions. Thermal ionization mass spectrometry of the Pb isotopes in the curse tablets appear to define a mixing line, with the tablets containing the least number of inclusions plotting closest to the Tunisian lead ore isotope ratios. 

In Figure 6, the curse tablet lead isotope ratios create an interesting pattern, with those tablets identified by EMPA analysis to contain the least number of inclusions plotting between two areas of Tunisian lead ores. The curse tablets identified as containing the greatest number of inclusions are those tablets plotting farthest away from the Tunisian lead ores. Additionally, the tablets appear to define a mixing line of ratios between two or more sources. 

Preliminary results based on these six curse tablets appear to validate the use of EMPA analysis to identify and classify curse tablets for further TIMS... 

Mean tablet hardness and hardness variability may influence the resulting dissolution profile, disintegration times, and tablet appearance. As shown in Table 6.16, the compression force strongly influences mean tablet hardness, while the dissolution profile and disintegration times are largely unaffected. 

The tablet was introduced by Thomas Brockedon in 1843, and glyceryl trinitrate tablets appeared in the British Pharmacopoeia of 1885. Since that... 

The hardness of a tablet is manipulated by adjusting the constituent proportions of sugars. Two forms of these tablets can be made one is called a hypodermic tablet, it easily dissolves in water and is not a hard tablet. These types of tablets break down (mechanically) very easily during storage and transport. The second type is harder and retains its shape in transport. A general formula for hard tablets appears in Remington s Practice of Pharmacy five parts lactose to one part sucrose. The composition is moistened with 70% alcohol and mixed thoroughly. 

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