Multiple sclerosis lesions appearance

Lindberg RL, DeGroot CJ, Certa U, Raviol T, Hoffmann F, Kappos L, Leppert D (2004) Multiple sclerosis as a generalized CNS disease—comparadvemicroarTay analysis of normal appearing white matter and lesions in secondary progressive multiple sclerosis. J Neuroimmunol 152 154—167. 

In the CNS, the major demyelinating disorder is multiple sclerosis (MS). MS should be differentiated from other disorders in which the histologic appearance of the lesions and the relapsing and remitting clinical course are similar. Acute MS lesions, in addition to plentiful foamy macrophages with increased proteases, have perivascular FCA-positive lymphocytes, EMA-positive and... 

---