Vascular smooth muscle cell proliferation

TASINATO A D, BOISCOBOINIK D, BARTOLI G M, MARONi p and Azzi A (1995) d-a-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its ntioydd ait xo eriie% Proceedings National Academy Sciences USA 92, 12190-4. 

Block of vascular smooth muscle cell proliferation Rat ICI 164384 (Cathapermal et al. 1998)... 

By acting on the vessel wall, estradiol significantly inhibited superoxide anion-induced vascular smooth muscle cell proliferation, whereas the pure antiestrogen ICI 164384 reversed the inhibitory effect of estradiol (Cathapermal et al. 1998). Fulvestrant also reversed the estradiol-induced increase in blood flow in rabbit aorta (Hegele-Hartung et al. 1997). 

JLompre I would like to present some of our results describing the changes that occur to cells in culture. My concern is primarily with the organization of the SR when vascular smooth muscle cells proliferate in culture. This is of interest because of the importance of smooth muscle cell proliferation in atherosclerosis and restenosis. Freshly dissociated cells or those that have been cultured for just one... 

Tulis DA, Mnjoyan ZH, Schiesser RL, et al. Adenoviral gene transfer of fortilin attenuates neointima formation through suppression of vascular smooth muscle cell proliferation and migration. Circulation. Jan 7 2003 107(1) 98-105. 

Alcocer, F., Whitley, D., Salazar-Gonzalez, J.F., Jordan, W.D., Sellers, M.T., Eckhoff, D.E., Suzuki, K., MacRae, C., and Bland, K.L., Quercetin inhibits human vascular smooth muscle cell proliferation and migration. Surgery, 131, 198, 2002. 

Araim, O., Ballantyne, J., Waterhouse, A.L., and Sumpio, B.E., Inhibition of vascular smooth muscle cell proliferation with red wine and red wine polyphenols, J. Vase. Surg., 35, 1226, 2002. 

Locher, R., Emmanuele, L., Suter, P.M., Vetter, W., and Barton, M., Green tea polyphenols inhibit human vascular smooth muscle cell proliferation stimulated by native low-density lipoprotein, Eur. J. Pharmaeol, 434, 1, 2002. 

Kim TJ, Kim JH, Jin YR, Yun YP. 2006. The inhibitory effect and mechanism of luteolin 7-glucoside on rat aortic vascular smooth muscle cell proliferation. Arch Pharm Res 29 67-72. 

Jarvis, T.C., Alby, L.J., Beaudry, A.A., Wincott, F.E., Beigelman, L., McSwiggen, J.A., Usman, N. and Stinchcomb, D.T. (1996a) Inhibition of vascular smooth muscle cell proliferation by ribozy mes that cleave c-myb mRNA. RNA, 2,419—428. 

Lipskaia, L., del Monte, F., Capiod, T., Yacoubi, S., Hadri, L., Hours, M., Hajjar, R. J. and Lompre, A. M., 2005, Sarco/endoplasmic reticulum Ca2+-ATPase gene transfer reduces vascular smooth muscle cell proliferation and neointima formation in die rat. Circ Res 97, 488—95. 

Yu, Y., Sweeney, M., Zhang, S., Platoshyn, O., Landsberg, J., Rothman, A. and Yuan, J. X., 2003, PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression. Am J Physiol Cell Physiol 284, C316-30. 

Atorvastatin calcium possesses an anti-inflammatory property and reduces the accumulation of inflammatory cells in the atherosclerotic plaques. The drug also inhibits the vascular smooth muscle cell proliferation a key event in the atherogenesis. Atorvastatin also inhibits the platelet function, thereby limiting both the atherosclerosis and the superadded thrombosis and also improves the vascular endothelial function, largely through the amplification of nitric oxide (NO) generation [3-5]. 

Janssens S, Flaherty D, Nong Z, et al. Human endothelial nitric oxide synthase gene transfer inhibits vascular smooth muscle cell proliferation and neointima formation after balloon injury in rats. Circulation 1998 97 1274-1281. 

Harell RL, Rajanayagam S, Doanes AM, et al. Inhibition of vascular smooth muscle cell proliferation and neointimal accumulation by adenovirus-mediated gene transfer of cytosine deaminase, Circulation 1997 96 621-627. 

Gunn J, Holt CM, Francis SE, et al. The effect of oligonucleotides to c-myb on vascular smooth muscle cell proliferation and neointima formation after porcine coronary angioplasty, Circ Res I 997 80 520-53 I. 

Sugiki H. Suppression of vascular smooth muscle cell proliferation by an antisense oligonucleotide against PDGF receptor, Hokkaido Igaku Zasshi 1995 70(3) 485-495. 

Villa AE, Guzman LA, Poptic EJ, et al. Effects of antisense c-myb oligonucleotides on vascular smooth muscle cell proliferation and response to vessel wall injury. Circ Res 1995 76 505-513. 

While the thiazolidindiones enhance insulin-mediated glucose transport via binding to the peroxisome proliferator-activating receptor (PPAR-y), the presence of this receptor in vascular smooth muscle cells, inflammatory cells, and endothelial cells likely facilitates the drug s ability to inhibit vascular smooth muscle cell proliferation, reduce inflammation, improve dyslipidemia, and, by extension, reduce in-stent restenosis. 

Pulmonary vasculitis damage to vascular smooth muscle cells proliferation of endothelium and vascular connective tissue in the liver... 

Ignarro LJ, Buga GM, Wei LH, Bauer PM, Wu G, del Soldato P. 2001. Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation. Proc. Natl. Acad. Sci. USA 98 4202-8... 

It happens that NO potently inhibits not only vascular smooth muscle cell proliferation, but also the adhesion, aggregation, and activation of platelets. With this in mind, it will be interesting to see whether the diazeniumdiolated metal stents derivatized as in Figure 7 will both inhibit acute thrombotic failure via NO s antiplatelet activity as well as reduce restenosis risk by way of its cytostatic effect in vascular smooth muscle. 

S. Hoshi, M. Goto, N. Koyama, K. Nomoto, and H. Tanaka, Regulation of vascular smooth muscle cell proliferation by nuclear factor-kappaB and its inhibitor, I-kappaB, J Biol Chem 275, 883-889 (2000). 

Ping, O. Y., Peng, W. L., Xu, D. L., Lai, W. Y., and Xu, A. L. 2004. Green tea polyphenols inhibit advanced glycation end product-induced rat vascular smooth muscle cell proliferation. Diyi Junyi Daxue Xuebao 24 247-51. 

Newby, A. C., Southgate, K. M., and Assender, J. W. (1992). Inhibition of vascular smooth muscle cell proliferation by endothelium-dependent vasodilators. Herz 17, 291-299. Nunokawa, Y., and Tanaka, S. (1992). Interferon-gamma inhibits proliferation of rat vascular smooth muscle cells by nitric oxide generation. Biochem. Biophys. Res. Commun. 188, 409-415. 

Loesberg, C., Van Wijk, R., Zandbergen, J., van Aken, W. G., van Mourik, J. A., and de Groot, G. (1985). Cell cycle-dependent inhibition of human vascular smooth muscle cell proliferation by prostaglandin E,. Exp. Cell Res. 160, 117-125. 

The next step in this approach to restenosis prevention is to implant a device, fabricated from such a polymer, at the site of injury to determine whether vascular smooth muscle cell proliferation and platelet attachment... 

Mooradian, D. L., Hutsell, T. C., and Keefer, L. K. (1995). Nitric oxide (NO) donor molecules Effect of NO release rate on vascular smooth muscle cell proliferation in vitro. J. Cardiovasc. Pharmacol. 25, 674-678. 

Bennett MR, Angelini S, McEwan JR, J oe R, Newby AC, Evan GI (1994) Inhibition of vascular smooth muscle cell proliferation in vitro and in vivo by c-myc antisense oligodeoxynucleotides. J Clin Invest 93 820-828... 

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